ArticleJournal of animal science and biotechnology2022
Glyphosate exposure deteriorates oocyte meiotic maturation via induction of organelle dysfunctions in pigs.
Article in Journal of animal science and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Construction of an Adverse Outcome Pathway Framework for Glyphosate-Induced Female Reproductive Toxicity Based on Toxicity Pathways.Environment & health (Washington, D.C.) · 2026Review
- Dietary Glyphosate Exposure Disrupts Hepatic and Reproductive Function in Female Zebrafish at Regulatory Safe Levels.Toxics · 2026Article
- Sex-specific cardiac remodeling and metabolic reprogramming in IUGR F2 fetuses following glyphosate or glyphosate-based herbicide exposure.Frontiers in toxicology · 2026Article
- Melatonin Rescues Triclosan-Disrupted Porcine Oocyte Meiosis via Suppression of p53-Mediated Apoptosis.Animals : an open access journal from MDPI · 2025Article
- Effects of Alpha-Lipoic Acid on Glyphosate-Treated Human Granulosa Cells: A Cross-Sectional Study.Health science reports · 2025Article
- Unveiling the nexus between environmental exposures and testicular damages: revelations from autophagy and oxidative stress imbalance.Cell death discovery · 2025Review
- Triclosan Caused Oocyte Meiotic Arrest by Modulating Oxidative Stress, Organelle Dysfunctions, Autophagy, and Apoptosis in Pigs.Animals : an open access journal from MDPI · 2025Article
- Methyl Paraben Affects Porcine Oocyte Maturation Through Mitochondrial Dysfunction.Biomolecules · 2024Article
- Sterigmatocystin declines mouse oocyte quality by inducing ferroptosis and asymmetric division defects.Journal of ovarian research · 2024Article
- Calcium signaling in oocyte quality and functionality and its application.Frontiers in endocrinology · 2024Review
- Supplementation of SDF1 during Pig Oocyte In Vitro Maturation Improves Subsequent Embryo Development.Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRecently, defects in mammalian oocytes maturation induced by environmental pollution results in the decreasing animal reproduction. Animal exposed to glyphosate is largely unavoidable because glyphosate is one of the most widely used herbicide worldwide due to its high-efficiency and broad-spectrum effects, which causes glyphosate an environmental contaminant found in soil, water and food. During the last few years, the growing and wider use of glyphosate has raised great concerns about its effects of reproductive toxicity. In this study, using porcine models, we investigated effects of glyphosate on organelle functions during oocyte meiosis.
resultsThe results showed glyphosate exposure disrupted porcine oocyte maturation. Expression levels of cumulus expansion-related genes were interfered, further indicating the meiotic defects. The damaging effects were mediated by destruction of mitochondrial distribution and functions, which induced ROS accumulation and oxidative stress, also indicated by the decreased mRNA expression of related antioxidant enzyme genes. We also found an interference of endoplasmic reticulum (ER) distribution, disturbance of Ca
conclusionsCollectively, our study showed that exposed to glyphosate could affect animal reproduction by compromising the quality of oocytes through its wide toxic effects on organelle functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.