Evidence map›Paper›PMID 35799099›Full record

ArticleClinical and experimental dental research2022

The influence of proton pump inhibitors on tissue attachment around teeth and dental implants: A scoping review.

Bhavneet K Chawla, Robert E Cohen, Elizabeth M Stellrecht, Lisa M Yerke

Abstract readScoping Review
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental dental research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bhavneet K ChawlaDepartment of Periodontics and Endodontics, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, New York, USA.
Robert E CohenDepartment of Periodontics and Endodontics, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, New York, USA.
Elizabeth M StellrechtUniversity Libraries, University at Buffalo, The State University of New York, Buffalo, New York, USA.
Lisa M YerkeDepartment of Periodontics and Endodontics, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, New York, USA.ORCID 0000-0001-5272-2580

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesProton pump inhibitors, such as omeprazole and pantoprazole, are frequently prescribed for the treatment of acid reflux. However, those medications have been shown to affect a variety of physiologic processes, including bone homeostasis and the gastrointestinal microbiome. The objective of this study was to assess the relationship between proton pump inhibitors and attachment levels around teeth and dental implants. A scoping review was performed to assess the extent and quality of the relevant literature. MATERIALS AND

methodsWe used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for scoping reviews (PRISMA-ScR) and searched four relevant biomedical literature databases in addition to the grey literature. Keywords in the title and abstract fields, and subject headings for proton pump inhibitors, teeth, and dental implants were included as search terms.

resultsOverall search results identified 791 publications which, after applying the inclusion and exclusion criteria, yielded 27 publications that were further analyzed for relevance and quality of scientific evidence. The majority of eligible publications were retrospective cohort studies. Following critical analysis, 13 publications, including six abstracts, were used to assess the effect of proton pump inhibitors on tissue attachment around teeth and dental implants.

conclusionsThere are few high-quality studies describing the effect of proton pump inhibitors on tissue attachment around teeth and dental implants. Nevertheless, among the included papers with the fewest confounding factors, there was a positive relationship between proton pump inhibitors and soft tissue attachment levels around teeth, and a predominantly negative but variable effect of proton pump inhibitors on the bone level around dental implants. Additional well-controlled prospective studies are required to fully elucidate those relationships.

Indexed as

Dental ImplantsProton Pump InhibitorsHumansOmeprazolePantoprazoleRetrospective StudiesDental ImplantsOmeprazolePantoprazoleProton Pump Inhibitorsdental implantsperiodontal diseaseperiodontitisproton pump inhibitors

Identifiers

PMID35799099
PMCPMC9562794

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.