Evidence map›Paper›PMID 35799087›Full record

ArticleJournal of cardiovascular translational research2023

Morphology Optimization of Leaflet for Surgical Reconstruction of the Aortic Valve: In Vitro Test and Simulation-Based DOE Study.

Yong Feng, Bowen Zhang, Jianming Li, Wentao Yan, Bing Jia, Shengzhang Wang, Huifeng Zhang

Abstract read
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In one paragraph

Article in Journal of cardiovascular translational research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yong FengInstitute for Biomechanics, Department of Aeronautics and Astronautics, Fudan University, 200433, Shanghai, China.
Bowen ZhangInstitute for Biomechanics, Department of Aeronautics and Astronautics, Fudan University, 200433, Shanghai, China.
Jianming LiInstitute for Biomechanics, Department of Aeronautics and Astronautics, Fudan University, 200433, Shanghai, China.
Wentao YanInstitute for Biomechanics, Department of Aeronautics and Astronautics, Fudan University, 200433, Shanghai, China.
Bing JiaDepartment of Cardiothoracic Surgery, Children's Hospital of Fudan University, 201102, Shanghai, China.
Shengzhang WangInstitute for Biomechanics, Department of Aeronautics and Astronautics, Fudan University, 200433, Shanghai, China. szwang@fudan.edu.cn.ORCID 0000-0003-2364-3896
Huifeng ZhangDepartment of Cardiothoracic Surgery, Children's Hospital of Fudan University, 201102, Shanghai, China. pluckzhang@163.com.

Funding

National Natural Science Foundation of China 11872152National Natural Science Foundation of China 32071310
6 · The paper itself

Abstract

This study was to evaluate the impact of leaflet trimming strategy on the hemodynamic behaviors of the aortic valve after reconstructive surgery, and give recommendations based on design of experiment (DOE) and in vitro studies. An in vitro hemodynamic test was performed on the simulated surgical model to quantify the efficacy of conventional reconstructive surgery. The very same computational model was built and verified, on which the full factorial DOE was carried out to summarize the correlations between leaflet trimming parameters and valve hemodynamic characteristics. Hemodynamic characteristics of the valve substitute were significantly associated with leaflet trimming parameters. The total regurgitant and transvalvular regurgitant of the valve substitute were reduced by 27.44% and 13.61% after optimization of the leaflet design. Synthetic use of in vitro tests and DOE study based on computational models helped improve outcomes of the reconstruction of aortic valve by reducing free edge length and increasing commissure height and leaflet height.

Indexed as

Aortic ValveHeart Valve ProsthesisComputer SimulationHemodynamicsIn Vitro TechniquesModels, AnatomicProsthesis DesignAortic valve reconstructionDesign of experimentFluid-structure interactionOptimization methodsPulsatile flow test

Identifiers

PMID35799087

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.