ArticleNature neuroscience2022
Memory-enhancing properties of sleep depend on the oscillatory amplitude of norepinephrine.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 156 papers.
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Who cites it
156 citing papers in PubMed, 267 citations in OpenAlex.
- A new hope: locus coeruleus-norepinephrine system at the nexus of neuropsychiatric symptoms.Molecular psychiatry · 2026Review
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- Astrocytic adrenergic α2 receptor contributes to the mechanisms underlying the circadian rhythmicity of seizure susceptibility.Acta pharmacologica Sinica · 2026Article
- Are infraslow oscillations the missing link between sleep and Alzheimer's?Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
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- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
- Refined Division of Sleep Stages in the Mouse Based on Distributed Deep Electrodes and Underlying Infra-Slow Oscillation.Journal of sleep research · 2026Article
- Energy paradox in REM sleep: balancing supply and consumption in brain metabolism.Communications biology · 2026Article
- The glymphatic system in sleep: a nexus of waste clearance, brain homeostasis, and disease intervention.Molecular psychiatry · 2026Review
- A molecular integrator of sleep duration and interruption.bioRxiv : the preprint server for biology · 2026Article
- Infra-slow (<0.1 Hz) Modulation of Human Brain Pulsations in Awake and Sleep States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Low-dimensional population dynamics in the brainstem gate REM sleep.Nature neuroscience · 2026Article
- Arousal state modulates human hippocampal ripples.bioRxiv : the preprint server for biology · 2026Article
- Noradrenergic infraslow rhythm during sleep is the critical link between heart-rate dynamics and memory consolidation.bioRxiv : the preprint server for biology · 2026Article
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Respiratory pauses highlight sleep architecture in mice.Nature communications · 2026Article
- Associations between REM-related respiratory disturbances, metabolic biomarkers, and memory impairment in pediatric sleep-disordered breathing.Pediatric research · 2026Article
96 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors at 3 institutions in 3 countries.
Funding
Abstract
Sleep has a complex micro-architecture, encompassing micro-arousals, sleep spindles and transitions between sleep stages. Fragmented sleep impairs memory consolidation, whereas spindle-rich and delta-rich non-rapid eye movement (NREM) sleep and rapid eye movement (REM) sleep promote it. However, the relationship between micro-arousals and memory-promoting aspects of sleep remains unclear. In this study, we used fiber photometry in mice to examine how release of the arousal mediator norepinephrine (NE) shapes sleep micro-architecture. Here we show that micro-arousals are generated in a periodic pattern during NREM sleep, riding on the peak of locus-coeruleus-generated infraslow oscillations of extracellular NE, whereas descending phases of NE oscillations drive spindles. The amplitude of NE oscillations is crucial for shaping sleep micro-architecture related to memory performance: prolonged descent of NE promotes spindle-enriched intermediate state and REM sleep but also associates with awakenings, whereas shorter NE descents uphold NREM sleep and micro-arousals. Thus, the NE oscillatory amplitude may be a target for improving sleep in sleep disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.