ArticleNature microbiology2022
The evolutionary origin of host association in the Rickettsiales.
Article in Nature microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed.
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- Tick cells as a tractable arthropod model for studyingApplied and environmental microbiology · 2026Article
- Adaptation to a host-associated lifestyle is associated with convergent loss of flagella-related genes in Pseudomonadota.BMC genomics · 2026Article
- Magnetoreception in a freshwater ciliate arises from endosymbiosis.Nature communications · 2026Article
- Sand fly endosymbionts in Kenya: Rickettsia and Wolbachia associations with Leishmania and detection of Rickettsia africae.Parasites & vectors · 2026Article
- A hot origin of dissimilatory sulfite reduction catalyzed by DsrAB in the Paleoarchean Era.mLife · 2026Article
- Facultative mutualism betweenISME communications · 2026Article
- Microbiome modulation in regeneration in jellyfish.PloS one · 2026Article
- A genomic view of Earth's biomes.Nature reviews. Genetics · 2026Review
- A Low-Cost, High-Fat Diet Effectively Induces Obesity and Metabolic Alterations and Diet Normalization Modulates Microbiota in C57BL/6 Mice.Nutrients · 2025Article
- Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease.PLoS pathogens · 2025Article
- An Evolutionary-Focused Review of the Holosporales (Alphaproteobacteria): Diversity, Host Interactions, and Taxonomic Re-ranking as Holosporineae Subord. Nov.Microbial ecology · 2025Review
- Extensive and diverse lanthanide-dependent metabolism in the ocean.The ISME journal · 2025Article
- The facultative intracellular symbiontFrontiers in microbiology · 2025Article
- Resistance ofInsects · 2024Article
- Addictive manipulation: a perspective on the role of reproductive parasitism in the evolution of bacteria-eukaryote symbioses.Biology letters · 2024Review
- OrthoPhyl-streamlining large-scale, orthology-based phylogenomic studies of bacteria at broad evolutionary scales.G3 (Bethesda, Md.) · 2024Article
- Host-bacteria interactions: ecological and evolutionary insights from ancient, professional endosymbionts.FEMS microbiology reviews · 2024Review
- "Candidatus Intestinibacterium parameciiphilum"-member of the "Candidatus Paracaedibacteraceae" family (Alphaproteobacteria, Holosporales) inhabiting the ciliated protist Paramecium.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
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Abstract
The evolution of obligate host-association of bacterial symbionts and pathogens remains poorly understood. The Rickettsiales are an alphaproteobacterial order of obligate endosymbionts and parasites that infect a wide variety of eukaryotic hosts, including humans, livestock, insects and protists. Induced by their host-associated lifestyle, Rickettsiales genomes have undergone reductive evolution, leading to small, AT-rich genomes with limited metabolic capacities. Here we uncover eleven deep-branching alphaproteobacterial metagenome assembled genomes from aquatic environments, including data from the Tara Oceans initiative and other publicly available datasets, distributed over three previously undescribed Rickettsiales-related clades. Phylogenomic analyses reveal that two of these clades, Mitibacteraceae and Athabascaceae, branch sister to all previously sampled Rickettsiales. The third clade, Gamibacteraceae, branch sister to the recently identified ectosymbiotic 'Candidatus Deianiraea vastatrix'. Comparative analyses indicate that the gene complement of Mitibacteraceae and Athabascaceae is reminiscent of that of free-living and biofilm-associated bacteria. Ancestral genome content reconstruction across the Rickettsiales species tree further suggests that the evolution of host association in Rickettsiales was a gradual process that may have involved the repurposing of a type IV secretion system.
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