ArticleScientific reports2022
Muscle coordination retraining inspired by musculoskeletal simulations reduces knee contact force.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06208631 (Effects of Haptic Movement Retraining on Osteoarthritis Progression), which is not on this map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Haptic Movement Retraining on Osteoarthritis Progression
Who cites it
48 citing papers in PubMed, 91 citations in OpenAlex.
- The energetic cost of human standing balance and gait initiation over a range of natural postures.PLoS computational biology · 2026Article
- Effects of bone deformation on patient-specific finite element predictions of hip chondrolabral mechanics.Journal of the mechanical behavior of biomedical materials · 2026Article
- Predictive Neuromechanical Simulation Explains Gait Biomechanics in Obesity.bioRxiv : the preprint server for biology · 2026Article
- Estimating and interpreting how humans prioritize multiple movement goals during walking.Journal of neuroengineering and rehabilitation · 2026Article
- Exploring the effect of different neural strategies on the knee joint contact forces during walking in adults.Scientific reports · 2026Article
- Immediate reductions in compressive and shear forces in the knee from gait retraining are associated with slowed cartilage degeneration after 1 year in medial knee osteoarthritis: A retrospective observational cohort study.Osteoarthritis and cartilage · 2026Observational
- Study on the Influence of Protector Design on the Biomechanical Characteristics of Knee Joint Movement.Sensors (Basel, Switzerland) · 2026Article
- Concurrent validation of OpenCap for identifying ACL re-injury risk factors during a drop jump test in a healthy cohort.Scientific reports · 2026Article
- Reproducible Research: Computational Design of Personalized Clinical Treatments for Walking Impairments Using the Neuromusculoskeletal Modeling Pipeline.bioRxiv : the preprint server for biology · 2026Article
- Evidence-informed methodological approaches for coupled neuromusculoskeletal-finite element analysis workflows in orthopaedic biomechanics.Frontiers in bioengineering and biotechnology · 2026Article
- Retraining Gastrocnemius Muscle Coordination Reduces Late-Stance Knee Contact Force in Individuals With Knee Osteoarthritis.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Ankle Exoskeleton Assistance Reduces Knee Contact Force During Walking in Individuals With Cerebral Palsy.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Foot progression angle modifications alter hip joint contact forces and femoral growth plate mechanics in children.Frontiers in bioengineering and biotechnology · 2026Article
- Patient-Perceived feasibility of implementing OpenCap smartphone-based motion capture technology to remotely assess musculoskeletal movement in individuals with orthopedic disorders presenting to a rural midwestern tertiary center.Frontiers in digital health · 2026Article
- Feasibility of Smartphone-Based Markerless Motion Capture for Quantitative Gait Assessment in Pediatric Guillain-Barré Syndrome: A Two-Case Proof-of-Concept Study.Bioengineering (Basel, Switzerland) · 2025Article
- Advancements in Understanding Spasticity: A Neuromusculoskeletal Modeling Perspective.Journal of clinical medicine · 2025Review
- Do Kinematics or Muscle Function During Sit-to-Stand Change Following a Primary Total Knee Arthroplasty?Annals of biomedical engineering · 2025Article
- Reduced Muscle Strength Can Alter the Impact of Gait Modifications on Knee Cartilage Mechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- How peak knee loads are affected by changing the mass of lower-limb body segments during walking.PLoS computational biology · 2025Article
- Computational Analysis of Neuromuscular Adaptations to Strength and Plyometric Training: An Integrated Modeling Study.Sports (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Humans typically coordinate their muscles to meet movement objectives like minimizing energy expenditure. In the presence of pathology, new objectives gain importance, like reducing loading in an osteoarthritic joint, but people often do not change their muscle coordination patterns to meet these new objectives. Here we use musculoskeletal simulations to identify simple changes in coordination that can be taught using electromyographic biofeedback, achieving the therapeutic goal of reducing joint loading. Our simulations predicted that changing the relative activation of two redundant ankle plantarflexor muscles-the gastrocnemius and soleus-could reduce knee contact force during walking, but it was unclear whether humans could re-coordinate redundant muscles during a complex task like walking. Our experiments showed that after a single session of walking with biofeedback of summary measures of plantarflexor muscle activation, healthy individuals reduced the ratio of gastrocnemius-to-soleus muscle activation by 25 ± 15% (p = 0.004, paired t test, n = 10). Participants who walked with this "gastrocnemius avoidance" gait pattern reduced late-stance knee contact force by 12 ± 12% (p = 0.029, paired t test, n = 8). Simulation-informed coordination retraining could be a promising treatment for knee osteoarthritis and a powerful tool for optimizing coordination for a variety of rehabilitation and performance applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.