Evidence map›Paper›PMID 35798752›Full record

ArticleNature communications2022

Nanoscale organization of two-dimensional multimeric pMHC reagents with DNA origami for CD8

Yueyang Sun, Lu Yan, Jiajia Sun, Mingshu Xiao, Wei Lai, Guangqi Song, Li Li, Chunhai Fan, Hao Pei

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Affinity Enhancement in Discrete Multivalent MegaMolecules.Chembiochem : a European journal of chemical biology · 2026
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  8. Rapid Genotyping ofBiomolecules · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yueyang SunShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, China.
Lu YanShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, China.
Jiajia SunShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, China.
Mingshu XiaoShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, China.
Wei LaiShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, China.ORCID 0000-0003-1428-0667
Guangqi SongDepartment of Gastroenterology and Hepatology, Zhongshan Hospital of Fudan University, Shanghai, China.
Li LiShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, China.ORCID 0000-0001-8494-4997
Chunhai FanSchool of Chemistry and Chemical Engineering, and Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, 200240, Shanghai, China.ORCID 0000-0002-7171-7338
Hao PeiShanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, 200241, Shanghai, China. peihao@chem.ecnu.edu.cn.ORCID 0000-0002-6885-6708
East China Normal University · CNShanghai Jiao Tong University · CNSun Yat-sen University · CNXi'an Peihua University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Peptide-MHC (pMHC) multimers have excelled in the detection of antigen-specific T cells and have allowed phenotypic analysis using other reagents, but their use for detection of low-affinity T cells remains a challenge. Here we develop a multimeric T cell identifying reagent platform using two-dimensional DNA origami scaffolds to spatially organize pMHCs (termed as dorimers) with nanoscale control. We show that these dorimers enhance the binding avidity for low-affinity antigen-specific T cell receptors (TCRs). The dorimers are able to detect more antigen-specific T cells in mouse CD8

Indexed as

CD8-Positive T-LymphocytesReceptors, Antigen, T-CellAnimalsDNAIndicators and ReagentsMiceDNAIndicators and ReagentsReceptors, Antigen, T-Cell

Identifiers

PMID35798752
PMCPMC9263106
OpenAlexW4284885415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.