ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Multimodal Noninvasive Functional Neurophotonic Imaging of Murine Brain-Wide Sensory Responses.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 35 citations in OpenAlex.
- Differential aperture modulation enables high-fidelity 3D photoacoustic imaging.Photoacoustics · 2026Article
- Optoacoustic brain imaging: A systematic review and field mapping.Photoacoustics · 2026Article
- Laser Ultrasound Super-Resolution Imaging for Multi-Parametric Non-Invasive Volumetric Characterization of Brain Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A cortex-wide multimodal microscope for simultaneous CaNature communications · 2025Article
- Non-invasive large-scale imaging of concurrent neuronal, astrocytic, and hemodynamic activity with hybrid multiplexed fluorescence and magnetic resonance imaging (HyFMRI).Light, science & applications · 2025Article
- Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography.Light, science & applications · 2025Article
- Simultaneous head-mounted imaging of neural and hemodynamic activities at high spatiotemporal resolution in freely behaving mice.Science advances · 2025Article
- Multimodal fluorescence-optoacousticPhotoacoustics · 2025Article
- Scalable Copper Sulfide Formulations for Super-Resolution Optoacoustic Brain Imaging in the Second Near-Infrared Window.Small methods · 2025Article
- Spiral volumetric optoacoustic tomography of reduced oxygen saturation in the spinal cord of M83 mouse model of Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2025Article
- Concurrent optoacoustic tomography and magnetic resonance imaging of resting-state functional connectivity in the mouse brain.Nature communications · 2024Article
- Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo.Brain pathology (Zurich, Switzerland) · 2024Article
- In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons.Nature communications · 2024Article
- High Spatiotemporal Resolution Radial Encoding Single-Vessel fMRI.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Multimodal optoacoustic imaging: methods and contrast materials.Chemical Society reviews · 2024Review
- Noninvasive Tracking of Embryonic Cardiac Dynamics and Development with Volumetric Optoacoustic Spectroscopy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cortex-wide transcranial localization microscopy with fluorescently labeled red blood cells.Nature communications · 2024Article
- Advancing insights into in vivo meningeal lymphatic vessels with stereoscopic wide-field photoacoustic microscopy.Light, science & applications · 2024Article
- Functional photoacoustic imaging: from nano- and micro- to macro-scale.Nano convergence · 2023Review
- Volumetric registration framework for multimodal functional magnetic resonance and optoacoustic tomography of the rodent brain.Photoacoustics · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Modern optical neuroimaging approaches are expanding the ability to elucidate complex brain function. Diverse imaging contrasts enable direct observation of neural activity with functional sensors along with the induced hemodynamic responses. To date, decoupling the complex interplay of neurovascular coupling and dynamical physiological states has remained challenging when employing single-modality functional neuroimaging readings. A hybrid fluorescence optoacoustic tomography platform combined with a custom data processing pipeline based on statistical parametric mapping is devised, attaining the first noninvasive observation of simultaneous calcium and hemodynamic activation patterns using optical contrasts. Correlated changes in the oxy- and deoxygenated hemoglobin, total hemoglobin, oxygen saturation, and rapid GCaMP6f fluorescence signals are observed in response to peripheral sensory stimulation. While the concurrent epifluorescence serves to corroborate and complement the functional optoacoustic observations, the latter further aids in decoupling the rapid calcium responses from the slowly varying background in the fluorescence recordings mediated by hemodynamic changes. The hybrid imaging platform expands the capabilities of conventional neuroimaging methods to provide more comprehensive functional readings for studying neurovascular and neurometabolic coupling mechanisms and related diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.