ArticleAnnals of pediatric endocrinology & metabolism2022
The association between C-reactive protein, metabolic syndrome, and prediabetes in Korean children and adolescents.
Article in Annals of pediatric endocrinology & metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Differential impact of maternal and paternal metabolic syndrome on offspring's cardiometabolic risk factors.Scientific reports · 2025Article
- Effects of multidisciplinary therapy on energy balance, inflammation, and metabolic diseases in adolescents with obesity: A narrative review.Annals of the New York Academy of Sciences · 2024Review
- Glycated albumin may have a complementary role to glycated hemoglobin in glucose monitoring in childhood acute leukemia.Annals of pediatric endocrinology & metabolism · 2024Article
- MicroRNAs as novel biomarkers for the diagnosis and treatment of pediatric diseases.Clinical and experimental pediatrics · 2024Article
- Association of Leukocyte, Erythrocyte, and Platelet Counts with Metabolic Syndrome and Its Components in Young Individuals without Overt Signs of Inflammation: A Cross-Sectional Study.Children (Basel, Switzerland) · 2024Article
- Management of Hyperphagia and Obesity in Prader-Willi Syndrome.Ewha medical journal · 2023Review
- C-Reactive Protein as a Marker of Inflammation in Children and Adolescents with Metabolic Syndrome: A Systematic Review and Meta-Analysis.Biomedicines · 2023Review
- Non-Traditional Cardiovascular Risk Factors in Adolescents with Obesity and Metabolic Syndrome May Predict Future Cardiovascular Disease.Nutrients · 2023Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeMetabolic syndrome (MetS) is a state of chronic inflammation, and high-sensitivity C-reactive protein (hsCRP) indicates inflammation. This paper evaluates the associations between hsCRP and MetS and its components in Korean children and adolescents.
methodsWe analyzed the data of 1,247 subjects (633 males, 14.2±2.7 years) from the Korea National Health and Nutrition Examination Survey 2016-2017. This study defined MetS and its components using the modified National Cholesterol Education Program-Adult Treatment Panel III (NCEP-ATP III) criteria.
resultsThe mean hsCRP level was 0.86±1.57 mg/dL (median and interquartile range: 0.37 and 0.43 mg/dL). Subjects with MetS had higher hsCRP level than subjects without MetS (geometric mean: 1.08 mg/dL vs. 0.46 mg/dL, p<0.001). With a higher quartile value of hsCRP, the prevalence of MetS increased. Compared to the lowest quartile, the odds ratio (OR) for MetS in the highest quartile was 7.34 (3.07-17.55) after adjusting for age and sex. In the top quartile of hsCRP, the risk of abdominal obesity and low HDL was high after adjusting for age, sex, and other components of MetS. Additionally, the OR for prediabetes (HbA1c ≥5.7%) in the highest quartile was 2.70.
conclusionSerum hsCRP level was positively associated with MetS and prediabetes using NCEP-ATP III criteria. Among the MetS components, abdominal obesity and low HDL were highly correlated with hsCRP in Korean children and adolescents.
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Registered trials
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