Evidence map›Paper›PMID 35798063›Full record

ArticleExperimental and molecular pathology2022

Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix.

Laurie B Joseph, Marion K Gordon, Peihong Zhou, Rita A Hahn, Hamdi Lababidi, Claire R Croutch, Patrick J Sinko, Diane E Heck, Debra L Laskin, Jeffrey D Laskin

Open access · greenAbstract read
In one paragraph

Article in Experimental and molecular pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Laurie B JosephDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America. Electronic address: lbjoseph@pharmacy.rutgers.edu.
Marion K GordonDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Peihong ZhouDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Rita A HahnDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Hamdi LababidiDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Claire R CroutchMRIGlobal, Kansas City, MO 64110, United States of America.
Patrick J SinkoDepartment of Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Diane E HeckDepartment of Public Health, New York Medical College, Valhalla, NY 10595, United States of America.
Debra L LaskinDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, United States of America.
Jeffrey D LaskinDepartment of Environmental and Occupational Health and Justice, Rutgers University School of Public Health, Piscataway, NJ 08854, United States of America.
Rutgers, The State University of New Jersey · USMRIGlobal · USNew York Medical College · US

Funding

UMDNJ/Rutgers University CounterACT Research Center of ExcellenceU54AR055073 · NIAMS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI HECK, DIANE E · 2006 to 2024
$71.4M
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
Summer Research Training in Environmental Health SciencesR25ES020721 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI Lauren M Aleksunes, Debra L Laskin · 2011 to 2026
$1.2M
NIAMS NIH HHS U54 AR055073NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R25 ES020721
6 · The paper itself

Abstract

Sulfur mustard (SM; bis(2-chloroethyl) sulfide) is a highly reactive bifunctional alkylating agent synthesized for chemical warfare. The eyes are particularly sensitive to SM where it causes irritation, pain, photophobia, and blepharitis, depending on the dose and duration of exposure. In these studies, we examined the effects of SM vapor on the corneas of New Zealand white male rabbits. Edema and hazing of the cornea, signs of acute injury, were observed within one day of exposure to SM, followed by neovascularization, a sign of chronic or late phase pathology, which persisted for at least 28 days. Significant epithelial-stromal separation ranging from ~8-17% of the epithelial surface was observed. In the stroma, there was a marked increase in CD45

Indexed as

Corneal InjuriesMustard GasAlkylating AgentsAnimalsBasement MembraneCollagenExtracellular MatrixFibronectinsHeparan Sulfate ProteoglycansMaleRabbitsSulfidesTenascinAlkylating AgentsCollagenFibronectinsHeparan Sulfate ProteoglycansMustard GasSulfidesTenascinBasement membraneCorneaPerlecanSulfur mustardTenacin-C

Identifiers

PMID35798063
PMCPMC10044521
OpenAlexW4283822802

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.