ArticleCurrent biology : CB2022
Structured sampling of olfactory input by the fly mushroom body.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 62 citations in OpenAlex.
- Article
- Structure, disorder, and dynamics in task-trained recurrent neural circuits.bioRxiv : the preprint server for biology · 2026Article
- Analysis of Dendritic Specializations in Two Classes of Kenyon Cells in the Mushroom Body of the Adult Honeybee, Apis mellifera.The Journal of comparative neurology · 2026Article
- Modular presynaptic assemblages scale to postsynaptic partner number.bioRxiv : the preprint server for biology · 2026Article
- Sensory processing reformats odor coding around valence and dynamics.bioRxiv : the preprint server for biology · 2025Article
- Spatial constraints and cell surface molecule depletion structure a randomly connected learning circuit.Current biology : CB · 2025Article
- Hybrid neural networks in the mushroom body drive olfactory preference inScience advances · 2025Article
- Article
- Convergence and divergence of diploid and tetraploid cotton genomes.Nature genetics · 2024Article
- Review
- Neuronal wiring diagram of an adult brain.Nature · 2024Article
- The primacy model and the structure of olfactory space.PLoS computational biology · 2024Article
- Synaptic connectome of a neurosecretory network in thebioRxiv : the preprint server for biology · 2024Article
- Diversity of visual inputs to Kenyon cells of the Drosophila mushroom body.Nature communications · 2024Article
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- Evolution of connectivity architecture in the Drosophila mushroom body.Nature communications · 2024Article
- What do the mushroom bodies do for the insect brain? Twenty-five years of progress.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Future avenues inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Sensory encoding and memory in the mushroom body: signals, noise, and variability.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- Modeling and characterization of pure and odorant mixture processing in theFrontiers in physiology · 2024Article
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 1 country.
Funding
Abstract
Associative memory formation and recall in the fruit fly Drosophila melanogaster is subserved by the mushroom body (MB). Upon arrival in the MB, sensory information undergoes a profound transformation from broadly tuned and stereotyped odorant responses in the olfactory projection neuron (PN) layer to narrowly tuned and nonstereotyped responses in the Kenyon cells (KCs). Theory and experiment suggest that this transformation is implemented by random connectivity between KCs and PNs. However, this hypothesis has been challenging to test, given the difficulty of mapping synaptic connections between large numbers of brain-spanning neurons. Here, we used a recent whole-brain electron microscopy volume of the adult fruit fly to map PN-to-KC connectivity at synaptic resolution. The PN-KC connectome revealed unexpected structure, with preponderantly food-responsive PN types converging at above-chance levels on downstream KCs. Axons of the overconvergent PN types tended to arborize near one another in the MB main calyx, making local KC dendrites more likely to receive input from those types. Overconvergent PN types preferentially co-arborize and connect with dendrites of αβ and α'β' KC subtypes. Computational simulation of the observed network showed degraded discrimination performance compared with a random network, except when all signal flowed through the overconvergent, primarily food-responsive PN types. Additional theory and experiment will be needed to fully characterize the impact of the observed non-random network structure on associative memory formation and recall.
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