Evidence map›Paper›PMID 35797764›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2022

Black-white Differences in Left Ventricular Hypertrophy Rates Among Young Adults with Ischemic Stroke.

Yan Hou, Kathleen A Ryan, Carolyn A Cronin, Elizabeth M Aradine, John W Cole, Seemant Chaturvedi, Marcella A Wozniak, Prachi Mehndiratta, Michael S Phipps, Karen L Yarbrough and 2 more

Open access · greenAbstract read
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In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Yan HouDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States.
Kathleen A RyanVA Maryland Health Care System, Baltimore, MD, United States; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Carolyn A CroninDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States; VA Maryland Health Care System, Baltimore, MD, United States.
Elizabeth M AradineDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States.
John W ColeDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States; VA Maryland Health Care System, Baltimore, MD, United States.
Seemant ChaturvediDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States; VA Maryland Health Care System, Baltimore, MD, United States.
Marcella A WozniakDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States; VA Maryland Health Care System, Baltimore, MD, United States.
Prachi MehndirattaDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States.
Michael S PhippsDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States; VA Maryland Health Care System, Baltimore, MD, United States.
Karen L YarbroughDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States.
Mohammad YousafDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States.
Steven J KittnerDepartment of Neurology, University of Maryland School of Medicine, 655 West Baltimore Street- Rm12-006, Baltimore, MD 21201-1559, United States; VA Maryland Health Care System, Baltimore, MD, United States. Electronic address: SKittner@umaryland.edu.
University of Maryland, Baltimore · US

Funding

Genetics of Early Onset-StrokeR01NS045012 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J · 2003 to 2007
$3.3M
Genetics of ischemic stroke in the SiGN ConsortiumR01NS100178 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2017 to 2021
$3.0M
Genetics of Early-Onset Ischemic Stroke ConsortiumR01NS105150 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI KITTNER, STEVEN J, MITCHELL, BRAXTON D · 2018 to 2022
$3.0M
CNV And Stroke (CaNVAS)R01NS114045 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI COLE, JOHN W. · 2020 to 2024
$2.6M
Whole Exome Sequencing Study of Early-Onset Ischemic StrokeI01BX004672 · VA · BALTIMORE VA MEDICAL CENTER · PI JOHN W. COLE · 2021 to 2026
–
BLRD VA I01 BX004672NINDS NIH HHS R01 NS045012NINDS NIH HHS R01 NS100178NINDS NIH HHS R01 NS105150NINDS NIH HHS R01 NS114045
6 · The paper itself

Abstract

objectivesFew studies have addressed Black-White differences in left ventricular hypertrophy (LVH) in young stroke patients without a history of hypertension.

methodsA case-only cross-sectional analysis performed in 2019 of data from the Stroke Prevention in Young Adults Study, a population-based case-control study of ischemic stroke patients ages 15-49. The main outcomes were hypertension indicators at the time of stroke hospitalization: self-reported history of hypertension, LVH by echocardiography (Echo-LVH) and LVH by electrocardiogram (ECG-LVH). The prevalence of Echo-LVH was further determined in those with and without a history of hypertension. Adjusted odds ratios and 95% confidence intervals comparing blacks and whites were calculated by logistic regression.

resultsThe study population included 1028 early-onset ischemic stroke patients, 48% Black cases, 54% men, median age 43 years (interquartile range, 38-46 years). Overall, the prevalence of hypertension history, Echo-LVH and ECG-LVH were 41.3%, 34.1% and 17.5%, respectively. Each of the hypertension indicators were more frequent in men than in women and in Black cases than in White cases. Black patients without a history of hypertension had higher rates of Echo-LVH than their white counterparts, 40.3% vs 27.7% (age and obesity adjusted OR 1.8; 95% CI 1.02-3.4) among men and 20.9% vs 7.6% (adjusted OR 2.7; 95% CI 1.2-6.2) among women.

conclusionsLVH was common in young patients with ischemic stroke, regardless of self-reported history of hypertension. These findings emphasize the need for earlier screening and more effective treatment of hypertension in young adults, particularly in the Black population.

Indexed as

HypertensionIschemic StrokeStrokeAdolescentAdultCase-Control StudiesCross-Sectional StudiesElectrocardiographyFemaleHumansHypertrophy, Left VentricularMaleMiddle AgedRisk FactorsYoung AdultHealth disparitiesHypertensionLeft ventricular hypertrophyStrokeYoung adults

Identifiers

PMID35797764
PMCPMC9347234
OpenAlexW4283810193

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.