Evidence map›Paper›PMID 35796919›Full record

ArticleLasers in medical science2022

Effect of ALA-PDT on inhibition of oral precancerous cell growth and its related mechanisms.

Jian-Qiu Jin, Qian Wang, Yu-Xing Zhang, Xing Wang, Zhi-Yue Lu, Bo-Wen Li

Abstract read
PubMed Publisher
In one paragraph

Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jian-Qiu Jin *Department of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
Qian Wang *Department of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
Yu-Xing ZhangDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China.
Xing WangInstitute of Stomatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, People's Republic of China. 1711110402@pku.edu.cn.
Zhi-Yue LuDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China. zhiyuel@263.net.
Bo-Wen LiDepartment of Stomatology, Beijing Hospital, National Center of Gerontology, Beijing, People's Republic of China. 15216402983@163.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CNBeijing Hospital · CNChinese PLA General Hospital · CN

Funding

National High Level Hospital Clinical Research Funding BJ-2022-177National Key R & D Program of China 2020YFC2009005the hospital level project of Beijing Hospital BJ-2021-206
6 · The paper itself

Abstract

backroundEarly treatment of oral precancerous lesions is considered as a key strategy for in oral carcinogenesis prevention. Increasing evidence has suggested that the transforming growth factor beta (TGF-β) signaling pathway is tightly involved in the process of oral-carcinogenesis. In this study, we investigated the inhibition effect and potential mechanism of 5-aminolaevulinic acid photodynamic therapy (ALA-PDT) in human oral precancerous cells via TGF-β pathway. MATERIALS AND

methodsHere, the dysplastic oral keratinocyte (DOK) cells were incubated with ALA concentration of 1 mM/mL for 4 h and then irradiated with a Helium-Neon (He-Ne) ion laser at 633 nm (200 mW/cm

resultsThe TGF-β signaling could exert in suppressive effects on DOK cells after ALA-PDT. The cell proliferation and migration rate of DOK cells was significantly reduced and apoptosis and ROS generation induced more effectively by ALA-PDT combined with LY2109761. Furthermore, cell cycle analysis revealed that the combined treatment resulted in G0/G1 phase arrest.

conclusionsALA-PDT suppresses the growth of oral precancerous cells by regulating the TGF-β signaling pathway, and its suppressive effect was enhanced using LY2109761. These results indicate that it could be a promising alternative treatment against oral precancerous lesions.

Indexed as

PhotochemotherapyPrecancerous ConditionsAminolevulinic AcidCarcinogenesisCell CycleCell Line, TumorCell ProliferationHumansPhotosensitizing AgentsTransforming Growth Factor betaAminolevulinic AcidPhotosensitizing AgentsTransforming Growth Factor betaIn vitroOral cancerOral precancerous lesionPhotodynamic therapyTransforming growth factor beta

Identifiers

PMID35796919
OpenAlexW4284884651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.