Evidence map›Paper›PMID 35796854›Full record

ArticleClinical neuroradiology2023

Outcome of Stroke Patients with Unknown Onset and Unknown Time Last Known Well Undergoing Endovascular Therapy.

Sebastian Stösser, Felix J Bode, Julius N Meissner, Johannes M Weller, Christine Kindler, Malte Sauer, Daniel Paech, Christoph Riegler, Christian H Nolte, Amitis Pourian and 10 more

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In one paragraph

Article in Clinical neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Sebastian StösserDivision of Vascular Neurology, Department of Neurology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany. sebastian.stoesser@ukbonn.de.ORCID http://orcid.org/0000-0002-1182-705X
Felix J BodeDivision of Vascular Neurology, Department of Neurology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Julius N MeissnerDivision of Vascular Neurology, Department of Neurology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Johannes M WellerDivision of Vascular Neurology, Department of Neurology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Christine KindlerDivision of Vascular Neurology, Department of Neurology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
Malte SauerDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Bonn, Bonn, Germany.
Daniel PaechDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0001-5755-6833
Christoph RieglerKlinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0002-2478-3500
Christian H NolteKlinik und Hochschulambulanz für Neurologie, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-5577-1775
Amitis PourianDepartment of Neurology, Asklepios Hospital Hamburg Altona, Semmelweis University Campus Hamburg, Hamburg, Germany.
Joachim RötherDepartment of Neurology, Asklepios Hospital Hamburg Altona, Semmelweis University Campus Hamburg, Hamburg, Germany.
Nadja SeloDepartment of Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Ulrike ErnemannDepartment of Neuroradiology, University Hospital Tübingen, Tübingen, Germany.
Sven PoliDepartment of Neurology, University Hospital Tübingen, Tübingen, Germany.
Rosa Marie EckertDepartment of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Georg BohnerDepartment of Neuroradiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Korbinian ScherlingDepartment of Neuroradiology, Ludwig Maximilians University Munich, Campus Grosshadern, Munich, Germany.
Franziska DornDepartment of Diagnostic and Interventional Neuroradiology, University Hospital Bonn, Bonn, Germany.
Gabor C PetzoldDivision of Vascular Neurology, Department of Neurology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.
GSR-ET study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeEndovascular treatment (ET) in patients with large vessel occlusion stroke (LVOS) with unknown onset or an extended time window can be safe and effective if patients are selected by defined clinical and imaging criteria; however, it is unclear if these criteria should also be applied to patients with unknown onset and unknown time last known well. In this study, we aimed to assess whether absent information on the time patients were last known to be well impacts outcome in patients with unknown onset LVOS.

methodsWe analyzed patients who were enrolled in the German Stroke Registry-Endovascular Treatment between 2015 and 2019. Patients with unknown onset and unknown time last known well (LKWu) were compared to patients with known onset (KO) and to patients with unknown onset but known time last known well (LKWk) regarding clinical and imaging baseline characteristics and outcome.

resultsOut of 5909 patients, 561 presented with LKWu (9.5%), 1849 with LKWk (31.3%) and 3499 with KO (59.2%). At 90 days, functional independency was less frequent in LKWu (27.0%) compared to KO (42.6%) and LKWk patients (31.8%). These differences were not significant after adjusting for confounders. A main confounder was the initial Alberta stroke program early CT score.

conclusionThe LKWu patients had a similar outcome after ET as KO and LKWk patients after adjusting for confounders. Thus, ET should not be withheld if the time last known well is unknown. Instead, LKWu patients may be selected for ET using the same criteria as in LKWk patients.

Indexed as

Endovascular ProceduresIschemic StrokeStrokeHumansThrombectomyTime FactorsAcute ischemic strokeLarge vessel occlusion strokeModified Rankin ScaleStroke registryThrombectomy

Identifiers

PMID35796854
PMCPMC10014703

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.