Evidence map›Paper›PMID 35796792›Full record

ArticleEuropean journal of pediatrics2022

Exploring the long-term colonisation and persistence of probiotic-prophylaxis species on the gut microbiome of preterm infants: a pilot study.

Jacob A F Westaway, Roger Huerlimann, Yoga Kandasamy, Catherine M Miller, Robert Norton, David Watson, Sandra Infante-Vilamil, Donna Rudd

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jacob A F WestawayCollege of Public Health, Medical and Veterinary Science, James Cook University, 1/14-88 McGregor Road, Smithfield, QLD, 4878, Australia. jacob.westaway@my.jcu.edu.au.ORCID http://orcid.org/0000-0002-5171-819X
Roger HuerlimannCentre for Tropical Bioinformatics and Molecular Biology, James Cook University, 1 James Cook Dr, Douglas, QLD, 4811, Australia.
Yoga KandasamyCollege of Public Health, Medical and Veterinary Science, James Cook University, 1 James Cook Dr, Douglas, QLD, 4811, Australia.
Catherine M MillerCollege of Public Health, Medical and Veterinary Science, James Cook University, 1/14-88 McGregor Road, Smithfield, QLD, 4878, Australia.
Robert NortonMicrobiology, Pathology Queensland, 100 Angus Smith Dr, Douglas, QLD, 4814, Australia.
David WatsonMaternal-Fetal Medicine, Townsville University Hospital, 100 Angus Smith Dr, Douglas, QLD, 4814, Australia.
Sandra Infante-VilamilCentre for Tropical Bioinformatics and Molecular Biology, James Cook University, 1 James Cook Dr, Douglas, QLD, 4811, Australia.
Donna RuddCollege of Public Health, Medical and Veterinary Science, James Cook University, 1 James Cook Dr, Douglas, QLD, 4811, Australia.
James Cook University · AUTownsville Hospital · AUAustralian Institute of Tropical Health and Medicine · AUOkinawa Institute of Science and Technology Graduate University · JPQueensland Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preterm infants suffer from a higher incidence of acute diseases such as necrotising enterocolitis and sepsis. This risk can be mitigated through probiotic prophylaxis during admission. This reduction in risk is likely the result of acute modulation of the gut microbiome induced by probiotic species, which has been observed to occur up until discharge. We aimed to determine if this modulation, and the associated probiotic species, persisted beyond discharge. We conducted both a cross-sectional analysis (n = 18), at ~ 18 months of age, and a longitudinal analysis (n = 6), from admission to 18 months of the gut microbiome of preterm infants using both shotgun metagenomics and 16S rRNA profiling respectively. The 16S amplicon sequencing revealed that the microbial composition of the probiotic-supplemented infants changed dramatically over time, stabilising at discharge. However, species from the probiotic Infloran

Indexed as

Enterocolitis, NecrotizingGastrointestinal MicrobiomeProbioticsAftercareCross-Sectional StudiesHumansInfantInfant, NewbornInfant, PrematurePatient DischargePilot ProjectsRNA, Ribosomal, 16SRNA, Ribosomal, 16SMicrobiomeNeonatalNICU & metagenomicsPreterm infantProbiotics

Identifiers

PMID35796792
PMCPMC9395480
OpenAlexW4284702517

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.