Evidence map›Paper›PMID 35796614›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Testosterone undecanoate administration prevents declines in fat-free mass but not physical performance during simulated multi-stressor military operations.

Alyssa N Varanoske, Melissa N Harris, Callie Hebert, Emily E Howard, Neil M Johannsen, Steven B Heymsfield, Frank L Greenway, Lee M Margolis, Harris R Lieberman, Robbie A Beyl and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Alyssa N VaranoskeMilitary Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts.ORCID 0000-0002-2001-6566
Melissa N HarrisPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana.
Callie HebertPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana.
Emily E HowardMilitary Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts.ORCID 0000-0001-7979-1236
Neil M JohannsenPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana.
Steven B HeymsfieldPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana.
Frank L GreenwayPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana.
Lee M MargolisMilitary Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts.ORCID 0000-0002-0652-1304
Harris R LiebermanMilitary Nutrition Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts.ORCID 0000-0002-1519-0156
Robbie A BeylPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana.
David D ChurchDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, Arkansas.ORCID 0000-0003-4918-5037
Arny A FerrandoDepartment of Geriatrics, Donald W. Reynolds Institute on Aging, Center for Translational Research in Aging & Longevity, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Stefan M PasiakosMilitary Performance Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts.
Jennifer C RoodPennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana.
Pennington Biomedical Research Center · USU.S. Army Research Institute of Environmental Medicine · USInstitute on Aging · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JUDD E SHELLITO · 2012 to 2026
$69.1M
Research BaseP30DK072476 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Sujoy Ghosh · 2005 to 2026
$26.5M
NIDDK NIH HHS P30 DK072476NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Male military personnel conducting strenuous operations experience reduced testosterone concentrations, muscle mass, and physical performance. Pharmacological restoration of normal testosterone concentrations may attenuate performance decrements by mitigating muscle mass loss. Previously, administering testosterone enanthate (200 mg/wk) during 28 days of energy deficit prompted supraphysiological testosterone concentrations and lean mass gain without preventing isokinetic/isometric deterioration. Whether administering a practical dose of testosterone protects muscle and performance during strenuous operations is undetermined. The objective of this study was to test the effects of a single dose of testosterone undecanoate on body composition and military-relevant physical performance during a simulated operation. After a 7-day baseline phase (

Indexed as

Military PersonnelBody CompositionHumansMalePolyestersTestosteronePolyestersTestosteronetestosterone undecanoateenergy deficithypogonadismlean body massskeletal musclestrength

Identifiers

PMID35796614
PMCPMC9359646
OpenAlexW4284885229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.