ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022
Inducing oscillations in positive end-expiratory pressure improves assessment of cerebrovascular pressure reactivity in patients with traumatic brain injury.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Microcirculation and Cerebrovascular Autoregulation in Patients With Mechanical Circulatory Support Devices.Journal of stroke · 2026Review
- On the utility of near-infrared spectroscopy-derived measures for assessing cerebrovascular autoregulation: results from an observational cohort study.Journal of clinical monitoring and computing · 2026Observational
- Monitoring of cerebral blood flow autoregulation: physiologic basis, measurement, and clinical implications.British journal of anaesthesia · 2024Review
- Effects of positive end-expiratory pressure on intracranial pressure, cerebral perfusion pressure, and brain oxygenation in acute brain injury: Friend or foe? A scoping review.Journal of intensive medicine · 2024Article
- Reliability and variability of pressure reactivity index (prx) during oscillatory pattern in arterial blood pressure and intracranial pressure in traumatic brain injured patients.Brain & spine · 2024Article
- Exploration of uncertainty of PRx time trends.Brain & spine · 2024Article
- Continuous monitoring of the lower limit of reactivity in traumatic brain injury patients: understanding what is feasible.Critical care (London, England) · 2023Article
- The pressure reactivity index as a measure of cerebral autoregulation and its application in traumatic brain injury management.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2023Review
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
Abstract
The cerebral pressure reactivity index (PRx), through intracranial pressure (ICP) measurements, informs clinicians about the cerebral autoregulation (CA) status in adult-sedated patients with traumatic brain injury (TBI). Using PRx in clinical practice is currently limited by variability over shorter monitoring periods. We applied an innovative method to reduce the PRx variability by ventilator-induced slow (1/min) positive end-expiratory pressure (PEEP) oscillations. We hypothesized that, as seen in a previous animal model, the PRx variability would be reduced by inducing slow arterial blood pressure (ABP) and ICP oscillations without other clinically relevant physiological changes. Patients with TBI were ventilated with a static PEEP for 30 min (PRx period) followed by a 30-min period of slow [1/min (0.0167 Hz)] +5 cmH
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