ArticleJournal of veterinary internal medicine2022
Characterization of the urogenital microbiome in Miniature Schnauzers with and without calcium oxalate urolithiasis.
Article in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of sample processing method and volume on 16 S rRNA profiling of the urobiome.BMC microbiology · 2026Article
- Serum and urine metabolomic profiling in Miniature Schnauzer dogs with and without calcium oxalate urolithiasis.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Evaluating urine volume and host depletion methods to enable genome-resolved metagenomics of the urobiome.Microbiome · 2025Article
- Evidence for an indigenous female mouse urobiome.PloS one · 2025Article
- Gut Microbiota Comparison in Rectal Swabs Versus Stool Samples in Cats with Kidney Stones.Microorganisms · 2024Article
- Evaluation of the vaginal and urinary microbiota of healthy cycling bitches.BMC veterinary research · 2024Article
- Dietary Features Are Associated with Differences in the Urinary Microbiome in Clinically Healthy Adult Dogs.Veterinary sciences · 2024Article
- Gut and Urinary Microbiota in Cats with Kidney Stones.Microorganisms · 2024Article
- The impact of urine collection method on canine urinary microbiota detection: a cross-sectional study.BMC microbiology · 2023Article
- Characterization of the urogenital microbiome in Miniature Schnauzers with and without calcium oxalate urolithiasis.Journal of veterinary internal medicine · 2022Article
- Estimates of Urinary Calcium Excretion in Dogs With and Without Calcium Oxalate Urolithiasis.Journal of veterinary internal medicineArticle
- Longitudinal examination of urine pH, specific gravity, protein, culture, and antimicrobial resistance profiles in healthy dogs.Journal of veterinary internal medicineArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundCalcium oxalate (CaOx) uroliths are common in dogs. Humans with CaOx urolithiasis exhibit alterations of the urinary and urogenital microbiomes that might mediate urolith formation. Detection of urogenital microbes associated with CaOx in dogs could inform disease pathophysiology.
objectiveTo identify compositional differences in the urogenital microbiome of Miniature Schnauzers with and without CaOx uroliths. ANIMALS: Nineteen midstream, voided urine samples from Miniature Schnauzers with (n = 9) and without (n = 10) a history of CaOx urolithiasis.
methodsAnalytical cross-sectional study. Microbial DNA was extracted from previously frozen urine samples and sequenced for the bacterial 16S rRNA V3-V4 hypervariable regions. Diversity and composition of microbial populations were compared between urolith formers and controls.
resultsAlpha and beta diversity measures were similar between groups. Five individual bacterial taxa differed in abundance (indicator values >0.5 and P < .05): Acinetobacter, 2 Geobacillus variants, and Hydrogenophaga were overrepresented in the urine of urolith formers, and Sphingopyxis was overrepresented in controls. Two distinct subtypes of urine microbial composition were observed based on beta diversity measures, independent of urolith status, and other clinical variables. CONCLUSIONS AND CLINICAL IMPORTANCE: Although we did not detect a difference in the overall urogenital microbial composition between groups, observed differences in individual bacterial taxa might be clinically relevant. For example, Acinetobacter was overrepresented in urolith formers and is associated with CaOx urolithiasis in humans. Two unique clusters of the microbiome were identified, independent of urolith status, which may represent distinct urotypes present in Miniature Schnauzers.
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