Evidence map›Paper›PMID 35796092›Full record

ArticleClinical & experimental ophthalmology2022

Quantification of localised vascular wedge-shaped defects in glaucoma.

Danit Saks, Angela Schulz, Samran Sheriff, Ting Shen, Vivek Gupta, Ayub Qassim, Bronwyn Ridge, Ryan Pham, Jamie Craig, Stuart Graham and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical & experimental ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
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  5. The Association ofJournal of clinical medicine · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Danit SaksDepartment of Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0001-5488-1884
Angela SchulzDepartment of Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia.ORCID 0000-0002-4254-7800
Samran SheriffDepartment of Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia.
Ting ShenDepartment of Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia.
Vivek GuptaDepartment of Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia.
Ayub QassimDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.
Bronwyn RidgeDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.
Ryan PhamDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.
Jamie CraigDepartment of Ophthalmology, Flinders Health and Medical Research Institute, Flinders University, Adelaide, South Australia, Australia.
Stuart GrahamDepartment of Clinical Medicine, Macquarie University, Sydney, New South Wales, Australia.
PROGRESSA Study Group
Macquarie University · AUFlinders University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVascular dysfunction plays a considerable role in glaucoma pathogenesis. Previous glaucoma case studies described localised wedge-shaped vascular defects, similar to retinal nerve fibre layer (RNFL) wedge defects. This study investigates the prevalence and quantification of this vessel loss, in relation to primary open angle glaucoma (POAG) parameters.

methodsThis study included 608 eyes (351 participants): 192 PROGRESSA study participants (342 eyes) with suspect, preperimetric or early manifest POAG, observed for vascular wedge defect presence (cohort one); an additional 114 individuals (cohort two-208 eyes) with POAG at various stages of progression for wedge characterisation; and 38 controls (56 eyes). Vascular wedge defects were observed using optical coherence tomography angiography (OCTA). Wedge parameters and vessel densities were quantified using ImageJ software. RNFL and ganglion cell layer inner plexiform layer (GCLIPL) from OCT scans, and mean deviation (Humphrey visual field 24-2) were also assessed.

resultsVascular wedge defects were found in 45/342 eyes (13.2%) in cohort one, in 41/208 eyes (19.7%) in cohort two and were not found in controls. Wedge defects were mostly inferotemporal (80%), and present at all disease stages. They were associated with visual field loss in the opposite hemisphere, thinner RNFL (p < 0.001), thinner GCLIPL (p = 0.003), and focal RNFL loss corresponding with the vascular defect region.

conclusionVascular wedge defects are present at all POAG stages even before functional change and are strongly concordant with focal RNFL loss. Further research is needed to explore these defects in particular their temporal relationship with clinical measures of POAG.

Indexed as

Glaucoma, Open-AngleOptic DiskHumansIntraocular PressureNerve FibersTomography, Optical CoherenceVisual Fieldsglaucomaimagingoptical coherence tomography angiographyvascular change

Identifiers

PMID35796092
PMCPMC9796144
OpenAlexW4284710150

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.