Evidence map›Paper›PMID 35795926›Full record

ArticleAnnals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc2022

Association of non-invasive electrocardiographic risk factors with left ventricular systolic function in post-myocardial infarction patients with mildly reduced or preserved ejection fraction: Insights from the PRESERVE-EF study.

Konstantinos P Tsimos, Panagiotis Korantzopoulos, Petros Arsenos, Ioannis Doundoulakis, Dimitrios Tsiachris, Christos-Konstantinos Antoniou, Konstantinos Krikonis, Skevos Sideris, Polychronis Dilaveris, Konstantinos Triantafyllou and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 1 country.

Konstantinos P TsimosFirst Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece.
Panagiotis KorantzopoulosFirst Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece.ORCID 0000-0002-4228-3593
Petros ArsenosFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-4426-8407
Ioannis DoundoulakisFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-2184-3296
Dimitrios TsiachrisFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Christos-Konstantinos AntoniouFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0002-6628-0303
Konstantinos KrikonisDatAnalysis, Ioannina, Greece.
Skevos SiderisState Department of Cardiology, Hippokrateion General Hospital, Athens, Greece.
Polychronis DilaverisFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-0399-4111
Konstantinos TriantafyllouThird Department of Cardiology, Aristotle University of Thessaloniki, Thessaloniki, Greece.ORCID 0000-0002-6117-2389
Stergios SoulaidopoulosFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.ORCID 0000-0003-4150-5286
Emmanuel KanoupakisDepartment of Cardiology, School of Medicine, Heraklion University Hospital, University of Crete, Heraklion, Greece.
Nikolaos FragakisThird Department of Cardiology, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Antonios SiderisSecond State Department of Cardiology, Evangelismos Athens General Hospital, Athens, Greece.
Konstantinos TrachanasState Department of Cardiology, Hippokrateion General Hospital, Athens, Greece.
Efstathios IliodromitisSecond Cardiology Department, Attikon Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios TousoulisFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos TsioufisFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Theofilos M KolettisFirst Department of Cardiology, University of Ioannina Medical School, Ioannina, Greece.
Konstantinos A GatzoulisFirst Department of Cardiology, Hippokrateion Hospital, National and Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GRUniversity of Ioannina · GRAristotle University of Thessaloniki · GRIppokrateio General Hospital of Thessaloniki · GREvangelismos Hospital · GRUniversity of Crete · GR

Funding

General Electric HealthcareMedtronic Hellas S.A.
6 · The paper itself

Abstract

backgroundElectrocardiographic non-invasive risk factors (NIRFs) have an important role in the arrhythmic risk stratification of post-myocardial infarction (post-MI) patients with preserved or mildly reduced left ventricular ejection fraction (LVEF). However, their specific relation to left ventricular systolic function remains unclear. We aimed to evaluate the association between NIRFs and LVEF in the patients included in the PRESERVE-EF trial.

methodsWe studied 575 post-MI ischemia-free patients with LVEF≥40% (mean age: 57.0 ± 10.4 years, 86.2% men). The following NIRFs were evaluated: premature ventricular complexes, non-sustained ventricular tachycardia (NSVT), late potentials (LPs), prolonged QTc, increased T-wave alternans, reduced heart rate variability, and abnormal deceleration capacity with abnormal turbulence.

resultsThere was a statistically significant relationship between LPs (Chi-squared = 4.975; p < .05), nsVT (Chi-squared = 5.749, p < .05), PVCs (r= -.136; p < .01), and the LVEF. The multivariate linear regression analysis showed that LPs (p = .001) and NSVT (p < .001) were significant predictors of the LVEF. The results of the multivariate logistic regression analysis indicated that LPs (OR: 1.76; 95% CI: 1.02-3.05; p = .004) and NSVT (OR: 2.44; 95% CI: 1.18-5.04; p = .001) were independent predictors of the mildly reduced LVEF: 40%-49% versus the preserved LVEF: ≥50%.

conclusionLate potentials and NSVT are independently related to reduced LVEF while they are independent predictors of mildly reduced LVEF versus the preserved LVEF. These findings may have important implications for the arrhythmic risk stratification of post-MI patients with mildly reduced or preserved LVEF.

Indexed as

Myocardial InfarctionVentricular Dysfunction, LeftVentricular Premature ComplexesAgedElectrocardiographyFemaleHumansLipopolysaccharidesMaleMiddle AgedRisk FactorsStroke VolumeVentricular Function, LeftLipopolysaccharideslate potentialsleft ventricular ejection fractionnon-invasive risk factorsnon-sustained ventricular tachycardiarisk stratification

Identifiers

PMID35795926
PMCPMC9484020
OpenAlexW4284881557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.