Evidence map›Paper›PMID 35795727›Full record

ArticleJournal of inflammation research2022

Anticipation of Relapse and Acute Graft-Versus-Host Disease after Allogeneic Peripheral Blood Stem Cell Transplantation: The Fundamental Role of Antigen-Presenting (Dendritic) Cells.

Khalid Ali Nasif, Awad S Al Samghan, Nahla El-Sharkawy, Amr M Abass, Ebtesam Elgezawy, Safaa A A Khaled, Mahmoud I Elbadry, Marwa M Thabet

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In one paragraph

Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Khalid Ali NasifClinical Biochemistry Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Awad S Al SamghanFamily and Community Medicine Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Nahla El-SharkawyClinical Pathology Department, National Cancer Institute, Cairo University, Cairo, Egypt.
Amr M AbassMedical Physiology Department, College of Medicine, King Khalid University, Abha, Saudi Arabia.
Ebtesam ElgezawyClinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
Safaa A A KhaledDepartment of Internal Medicine, Clinical Hematology Unit, AUH/Unit of Bone Marrow Transplantation, South Egypt Cancer Institute, Faculty of Medicine, Assiut University, Assiut, Egypt.ORCID 0000-0002-2239-7219
Mahmoud I ElbadryDepartment of Internal Medicine, Division of Haematology, Faculty of Medicine, Sohag University, Sohag, Egypt.ORCID 0000-0001-5487-9493
Marwa M ThabetClinical Pathology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.
King Khalid University · SAAssiut University · EGAsir Central Hospital · SACairo University · EGSohag University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dendritic cells (DCs) are antigen-presenting cells. In humans two distinct lineages of DCs exist: DC1 and DC2. Efforts to explore the role of DCs in acute graft-versus-host disease (aGVHD) after allogeneic peripheral blood stem-cell transplantation (PBSCT) are gaining traction. However, further research is needed to identify particular lineages and their values in terms of developing an evidence-based aGVHD- or relapse-prevention strategy. We monitored DC counts and subsets in PBSC grafts while harvesting stem cells in recipients to elucidate their value in anticipating disease relapse or aGVHD. Methods: We enrolled 29 participants. Using fluorescence-activated cell sorting, total counts/kg of CD34 Results: In the 29 grafts, we detected a significant positive correlation ( Conclusion: This study analyzed DCs in PBSC grafts, using novel specific MoAbs and flow cytometry. Our data showed that higher donor DC1 counts were linked to the incidence of aGVHD and DC2 with relapse. We propose a fundamental role for DC-graft monitoring in anticipating aGVHD and disease relapse.

Indexed as

acute GVHDallogeneic PBSCTbiomarkercelldendriticrelapse

Identifiers

PMID35795727
PMCPMC9252320
OpenAlexW4285744089

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.