Evidence map›Paper›PMID 35795688›Full record

ArticleFrontiers in molecular neuroscience2022

First Metabolomic Signature of Blood-Brain Barrier Opening Induced by Microbubble-Assisted Ultrasound.

Antoine Presset, Sylvie Bodard, Antoine Lefèvre, Anaïs Millet, Edward Oujagir, Camille Dupuy, Tarik Iazourène, Ayache Bouakaz, Patrick Emond, Jean-Michel Escoffre and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Engineered EVs designed to target diseases of the CNS.Journal of controlled release : official journal of the Controlled Release Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Antoine PressetUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Sylvie BodardUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Antoine LefèvreUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Anaïs MilletUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Edward OujagirUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Camille DupuyUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Tarik IazourèneUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Ayache BouakazUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Patrick EmondUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Jean-Michel EscoffreUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Lydie Nadal-DesbaratsUMR 1253, iBrain, Inserm, Université de Tours, Tours, France.
Inserm · FRUniversité de Tours · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbubble (MB)-assisted ultrasound (US) is a promising physical method to increase non-invasively, transiently, and precisely the permeability of the blood-brain barrier (BBB) to therapeutic molecules. Previous preclinical studies established the innocuity of this procedure using complementary analytical strategies including transcriptomics, histology, brain imaging, and behavioral tests. This cross-sectional study using rats aimed to investigate the metabolic processes following acoustically-mediated BBB opening

Indexed as

blood-brain barrier openingHPLC-MSinflammationmetabolomicsmicrobubbleneurotransmissionNMRultrasound

Identifiers

PMID35795688
PMCPMC9251546
OpenAlexW4283217998

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.