Evidence map›Paper›PMID 35795664›Full record

ReviewFrontiers in immunology2022

T Cell Extracellular Traps: Tipping the Balance Between Skin Health and Disease.

Kelsey Ouyang, Nicole Oparaugo, Amanda M Nelson, George W Agak

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Research progress on the neutrophil components and their interactions with immune cells in the development of psoriasis.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kelsey OuyangCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, United States.
Nicole OparaugoDavid Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, CA, United States.
Amanda M NelsonDepartment of Dermatology, Penn State University College of Medicine, Hershey, PA, United States.
George W AgakDivision of Dermatology, Department of Medicine, University of California, Los Angeles (UCLA), Los Angeles, CA, United States.
University of California, Los Angeles · USPenn State Milton S. Hershey Medical Center · US

Funding

The Role of T cell Extracellular Traps in Acne PathogenesisR01AR081337 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI George W Agak · 2022 to 2026
$2.2M
The nature of Propionibacterium acnes-induced inflammatory immune responses in acne vulgarisK01AR071479 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AGAK, GEORGE W · 2017 to 2022
$958k
NIAMS NIH HHS K01 AR071479NIAMS NIH HHS R01 AR081337
6 · The paper itself

Abstract

The role of extracellular traps (ETs) in the innate immune response against pathogens is well established. ETs were first identified in neutrophils and have since been identified in several other immune cells. Although the mechanistic details are not yet fully understood, recent reports have described antigen-specific T cells producing T cell extracellular traps (TETs). Depending on their location within the cutaneous environment, TETs may be beneficial to the host by their ability to limit the spread of pathogens and provide protection against damage to body tissues, and promote early wound healing and degradation of inflammatory mediators, leading to the resolution of inflammatory responses within the skin. However, ETs have also been associated with worse disease outcomes. Here, we consider host-microbe ET interactions by highlighting how cutaneous T cell-derived ETs aid in orchestrating host immune responses against

Indexed as

Acne VulgarisExtracellular TrapsHumansPropionibacterium acnesSkinT-LymphocytesacneCutibacterium acnes (C acnes)skinT cell extracellular trapsTH17 cell

Identifiers

PMID35795664
PMCPMC9250990
OpenAlexW4283164370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.