Evidence map›Paper›PMID 35795662›Full record

ArticleFrontiers in immunology2022

Immunity and Extracellular Matrix Characteristics of Breast Cancer Subtypes Based on Identification by T Helper Cells Profiling.

Yan Zhou, Qi Tian, Huan Gao, Lizhe Zhu, Ying Zhang, Chenchen Zhang, Jiao Yang, Bo Wang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Role of CD4Journal of translational medicine · 2025
    Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. YAP/STAT3 inhibited CD8Cancer medicine · 2023
    Article
  11. Article
  12. Increased expression ofFrontiers in genetics · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yan ZhouDepartment of Medical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Qi TianDepartment of Medical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Huan GaoDepartment of Medical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Lizhe ZhuDepartment of Breast Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Ying ZhangDepartment of Gastroenterology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Chenchen ZhangDepartment of Clinical Laboratory, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Key Laboratory of Stem Cells and Gene Drug in Gansu Province, Lanzhou, China.
Jiao YangDepartment of Medical Oncology, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Bo WangCenter for Translational Medicine, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNChinese People's Liberation Army · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The therapeutic effect of immune checkpoint inhibitors on tumors is not only related to CD8+ effector T cells but also sufficiently related to CD4+ helper T (T Methods: Breast cancer samples from The Cancer Genome Atlas (TCGA) database and triple-negative breast cancer (TNBC) samples from GSE31519 in the Gene Expression Omnibus (GEO) database were extracted and clustered based on gene sets representing T Results: The breast cancer samples from the datasets in TCGA database and GEO database were classified into T Conclusions: The immune and ECM characteristics of breast cancer subtypes based on T

Indexed as

Triple Negative Breast NeoplasmsExtracellular MatrixGene Expression ProfilingGene Expression Regulation, NeoplasticHumansT-Lymphocytes, Helper-InducerTumor Microenvironmentbreast cancerextracellular matrixT helper cell (Th)tumor immunitytumor microenvironment

Identifiers

PMID35795662
PMCPMC9251002
OpenAlexW4283160866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.