ReviewFrontiers in nutrition2022
Fruit and Vegetable Consumption and Cognitive Disorders in Older Adults: A Meta-Analysis of Observational Studies.
Review in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Association between plant-based diets and incident dementia: results from prospective cohort studies and a meta-analysis.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Pooled it
- Nutrition guidance within a multimodal intervention improves diet quality in prodromal Alzheimer's disease: Multimodal Preventive Trial for Alzheimer's Disease (MIND-ADAlzheimer's research & therapy · 2024Trial
- Dietary (Poly)phenol Intake, Inflammatory Biomarkers, and Mild Cognitive Impairment in Italian Adults.Antioxidants (Basel, Switzerland) · 2026Article
- [Modifiable risk and protective factors for dementia: an overview of established and emerging evidence].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2026Review
- Are avocados good for the brain? Most likely yes, in spite of their lack of effect on cognitive performance in a well-conducted 6-month randomized controlled trial.The journal of nutrition, health & aging · 2026Article
- Development of a clinical nomogram to assess the risk of cognitive impairment in community-dwelling middle-aged and older adults.BMC neurology · 2026Article
- What is the cost of dedication to teaching? A school-based longitudinal quantitative study on habits and quality of life.PloS one · 2026Article
- Adherence to the Mediterranean diet, inflammatory biomarkers and cognitive status in older Italian adults.Frontiers in nutrition · 2026Article
- Minimum pulse rate during sleep as a MMSE-associated factor: a multifaceted exploratory study in older adults without long-term care certification.BMC geriatrics · 2025Article
- Fruits as a preventative strategy: exploring their role in neurodegenerative disease management.Neurodegenerative disease management · 2025Review
- Consensus statement on exploring the Nexus between nutrition, brain health and dementia prevention.Nutrition & metabolism · 2025Review
- Diet, fruit and vegetables and One Health: benefits for health, environment, society and the consumer-proceedings of the 9th edition of EGEA conference.European journal of nutrition · 2025Article
- Lifestyle interventions for dementia risk reduction: A review on the role of physical activity and diet in Western and Asian Countries.The journal of prevention of Alzheimer's disease · 2025Review
- Factors Associated with Healthy Behavior for Preventing Non-Communicable Diseases.Journal of multidisciplinary healthcare · 2025Review
- Exploring cerebrospinal fluid metabolites, cognitive function, and brain atrophy: Insights from Mendelian randomization.Open medicine (Warsaw, Poland) · 2025Article
- Targeting the blood-brain barrier with phytochemicals to attenuate vascular cognitive impairment: mechanisms and therapeutic potential across etiologies.Frontiers in nutrition · 2025Review
- Behavioral change in fruit and vegetable consumption and associated cognitive impairment among Chinese older adults.European geriatric medicine · 2024Article
- Correlation between Vegetable and Fruit Intake and Cognitive Function in Older Adults: A Cross-Sectional Study in Chongqing, China.Nutrients · 2024Article
- Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: The aim of this meta-analysis was to assess the quantitative associations between fruit and vegetable intake and cognitive disorders in older adults. Design: A meta-analysis. Setting and Participants: We used the PubMed, Web of Science and Scopus databases for a literature search to 12 April 2022. We preliminarily retrieved 11,759 studies, 16 of which met the inclusion criteria including six cross-sectional studies, nine cohort studies and one case-control study, incorporating 64,348 participants and 9,879 cases. Methods: Using the three databases, we identified observational studies exploring the association. The pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using a random effects model. Results: Sixteen studies were included in the meta-analysis, and the results showed that increased fruit and vegetable consumption in older adults was associated with a decline in the prevalence of cognitive disorders (OR: 0.79, 95% CI: 0.76-0.83). Moreover, intake of fruits (OR: 0.83, 95% CI: 0.77-0.89) and vegetables (OR: 0.75, 95% CI: 0.70-0.80) alone were both associated with a lower prevalence of cognitive disorders. Subgroup analyses indicated that the intake of fruits and vegetables was associated with the prevalence of cognitive impairment (OR: 0.72, 95% CI: 0.76-0.80) and dementia (OR: 0.84, 95% CI: 0.78-0.91) but not Alzheimer's disease (OR: 0.88, 95% CI: 0.76-1.01). Conclusion and Implications: Our meta-analysis provides evidence that the intake of fruits and vegetables is inversely proportional and linearly associated with the prevalence of cognitive disorders in older adults. Future research is required to further investigate the preventive effects of the frequency, quantity, and duration of eating vegetables and fruits on cognitive disorders in older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.