ArticleIJU case reports2022
Pathological complete response of plasmacytoid variant bladder cancer to pembrolizumab following genomic analysis.
Article in IJU case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 6 citations in OpenAlex.
- Editorial Comment on "Recent Advances and Future Directions in Bladder Preservation Therapy for Muscle-Invasive Bladder Cancer".International journal of urology : official journal of the Japanese Urological Association · 2025Article
- Case report series: Pembrolizumab and enfortumab vedotin in plasmacytoid urothelial carcinoma.Frontiers in oncology · 2025Article
- A pathological complete response and adrenal insufficiency in a patient with advanced renal pelvic cancer treated with pembrolizumab.International cancer conference journal · 2024Article
- Molecular characterization of plasmacytoid urothelial carcinoma and the impact on treatment implications.Cancer treatment and research communications · 2023Review
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9 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Introduction: Plasmacytoid variant bladder cancer is a rare variant of urothelial carcinoma that accounts for 1% of bladder cancers. Plasmacytoid variant urothelial carcinoma is characterized by an aggressive phenotype and poor clinical outcomes. Case presentation: A 61-year-old woman presented with gross hematuria. Cystoscopy showed a 16-mm solid tumor. Transurethral resection of the bladder tumor was performed, and the pathological diagnosis was invasive plasmacytoid variant urothelial carcinoma. Although the pathological T stage was pT1, computed tomography showed right obturator lymph node swelling. Since previous reports indicate poor response to chemotherapy for this disease, clinical sequencing was performed. Based on the high tumor mutation burden revealed, pembrolizumab was administered for 4 cycles, and computed tomography showed a partial response. Robot-assisted radical cystectomy was performed, and a pathological complete response including the pelvic lymph node was observed. Conclusion: Pembrolizumab may be a treatment option for plasmacytoid variant urothelial carcinoma following genomic analysis.
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