Evidence map›Paper›PMID 35795076›Full record

ArticleAnalytical cellular pathology (Amsterdam)2022

Numb Promotes Autophagy through p53 Pathway in Acute Kidney Injury Induced by Cisplatin.

Ze Liu, Yong Li, Yongmei He, Junjie Wang

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ze LiuSchool of Nursing, Xiangnan University, Chenzhou, China.ORCID https://orcid.org/0000-0002-6434-7551
Yong LiDepartment of Medicine, Xiangnan University, Chenzhou, China.ORCID https://orcid.org/0000-0001-8130-0088
Yongmei HeSchool of Nursing, Xiangnan University, Chenzhou, China.ORCID https://orcid.org/0000-0002-5373-2446
Junjie WangSchool of Pharmacology, Xiangnan University, Chenzhou, China.ORCID https://orcid.org/0000-0003-4164-9458
Xiangnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute kidney injury (AKI) is an important public health concern and characterized as tubular death involved in apoptosis and necrosis. Autophagy is rapidly induced in tubules and associates with renal tubular cells homeostasis to have a complex link with tubular death in AKI. Numb is a multifunctional protein and exerts protective role in tubular death in AKI induced by Cisplatin. However, the effect of Numb on tubular autophagy remains to be investigated. In the present study, the protein expression of LC3 and Beclin-1 related to autophagy was analyzed in Cisplatin-induced AKI mice with knocking down Numb. In model of tubular injury induced by Cisplatin

Indexed as

Acute Kidney InjuryCisplatinTumor Suppressor Protein p53AnimalsAutophagyBeclin-1Membrane ProteinsMiceNerve Tissue ProteinsBeclin-1CisplatinMembrane ProteinsNerve Tissue ProteinsNumb protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53

Identifiers

PMID35795076
PMCPMC9252835
OpenAlexW4283651664

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.