ArticleOpen forum infectious diseases2022
Tuberculosis Among Patients With Systemic Lupus Erythematosus in Indonesia: A Cohort Study.
Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Pooled it
- Organ involvement and laboratory abnormalities associated with tuberculosis disease in systemic lupus erythematosus patients: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Autoimmune Diseases and Mycobacterial Infection.Diseases (Basel, Switzerland) · 2026Review
- Characteristics of indeterminate QuantiFERON-TB Gold PLUS results in pediatric lupus nephritis at Beijing Children's Hospital, 2023-2024.BMC nephrology · 2025Article
- Article
- Association Between 10 Autoimmune Diseases and Risk of Pulmonary Tuberculosis: A Mendelian Randomization Study.Journal of multidisciplinary healthcare · 2025Article
- Pharmacokinetic Profile of Isoniazid and Acetylator Status in Patients with Systemic Lupus Erythematosus: Implications for Tuberculosis Prevention Therapy in Indonesia.Infection and drug resistance · 2025Article
- Tuberculosis in patients with systemic lupus erythematosus.Frontiers in immunology · 2025Review
- Oral Lesion Management in Juvenile SLE with Hepatosplenomegaly.International medical case reports journal · 2024Article
- Diagnostic challenge of tuberculosis in systemic lupus erythematosus: a case report and literature review.Rheumatology international · 2023Review
- Incidence and risk factors of tuberculosis in systemic lupus erythematosus patients: a multi-center prospective cohort study.Frontiers in immunology · 2023Article
- Case Report: Tuberculosis lymphadenitis with systemic lupus erythematosus in a young woman: a case report.F1000Research · 2023Article
- Pregnancy-associatedIndian journal of sexually transmitted diseases and AIDSArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In previous studies, researchers have identified systemic lupus erythematosus (SLE) as a risk factor for tuberculosis (TB), but data from TB-endemic countries are still relatively scarce. We examined TB in a large cohort of SLE patients in Indonesia. Methods: All patients registered in a lupus registry of the top referral hospital for West Java between 2008 and 2020 were included. Data on SLE characteristics and treatment were retrieved from the registry, and data on TB diagnosis, localization, and outcome were extracted from medical records. Cox-proportional hazard model was used to examine risk factors for development of TB. Results: Among 1278 SLE patients observed over a total of 4804 patient-years, 131 patients experienced 138 episodes of TB, a median of 2 years (interquartile range, 0.6-5.4) after diagnosis of SLE. A total of 113 patients (81.9%) had pulmonary involvement and 61 (44.2%) had extrapulmonary involvement, with disseminated disease in 26 of 138 episodes (18.8%), and 13 of 131 patients (9.9%) died from TB. The estimated TB incidence was 2873 cases per 100 000 person years. In multivariate cox regression analysis, development of TB was associated with household TB contact (hazard ratio [HR], 7.20; 95% confidence interval [CI], 4.05-12.80), pulse methylprednisolone therapy (HR, 1.64; 95% CI, 1.01-2.67), and age ≤25 years old at SLE diagnosis (HR, 1.54; 95% CI, 1.00-2.35). Conclusions: There is a high burden of TB in SLE patients in this TB-endemic setting, underlining the need for evaluation or implementation of TB preventive strategies.
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Registered trials
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