Evidence map›Paper›PMID 35794920›Full record

ArticleFrontiers in microbiology2022

Identification and Engineering of Transporters for Efficient Melatonin Production in

Lei Yang, Sailesh Malla, Emre Özdemir, Se Hyeuk Kim, Rebecca Lennen, Hanne B Christensen, Ulla Christensen, Lachlan J Munro, Markus J Herrgård, Douglas B Kell and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Analysis of a Library ofAntibiotics (Basel, Switzerland) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Lei YangNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Sailesh MallaNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Emre ÖzdemirNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Se Hyeuk KimNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Rebecca LennenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Hanne B ChristensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Ulla ChristensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Lachlan J MunroNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Markus J HerrgårdNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Douglas B KellNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Bernhard Ø PalssonNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Lyngby, Denmark.
Technical University of Denmark · DKNovo Nordisk Foundation · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transporter discovery and engineering play an important role in cell factory development. Decreasing the intracellular concentration of the product reduces product inhibition and/or toxicity. Lowering intracellular concentrations is especially beneficial for achieving a robust strain at high titers. However, the identification of transporters for xenobiotic chemicals in the host strain is challenging. Here we present a high-throughput workflow to discover

Indexed as

E. coliidentificationinhibitionmembraneproductionscreeningtoxicitytransporter

Identifiers

PMID35794920
PMCPMC9251470
OpenAlexW4283220933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.