Evidence map›Paper›PMID 35794768›Full record

ArticleCurrent neuropharmacology2023

Advanced Microfluidic Vascularized Tissues as Platform for the Study of Human Diseases and Drug Development.

Behnam Noorani, Luca Cucullo, Yeseul Ahn, Hossam Kadry, Aditya Bhalerao, Snehal Raut, Ehsan Nozohouri, Ekram Ahmed Chowdhury

Abstract read
In one paragraph

Article in Current neuropharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Behnam NooraniDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.
Luca CuculloDepartment of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USA.
Yeseul AhnDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.
Hossam KadryDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.
Aditya BhaleraoDepartment of Foundation Medical Studies, Oakland University, William Beaumont School of Medicine, 586 Pioneer Dr, Rochester, MI 48309, USA.
Snehal RautDepartment of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USA.
Ehsan NozohouriDepartment of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX, 79106, USA.
Ekram Ahmed ChowdhuryDepartment of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, The State University of New York at Buffalo, New York, USA.

Funding

Repurposing Metformin to Offset Stroke Risk and Injury in Comorbid Populations of SmokersR01NS117906 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ABBRUSCATO, THOMAS J, CUCULLO, LUCA · 2020 to 2024
$2.9M
Tobacco Smoke Chemicals and Stroke Alter Brain K+ EffluxR01NS046526 · NINDS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ABBRUSCATO, THOMAS J · 2004 to 2008
$1.5M
Blood and Brain Based Biomarkers of Injury to Assess the Cerebrovascular Impact of Emerging Alternatives to Classic Cigarette ProductsR01DA049737 · NIDA · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI ABBRUSCATO, THOMAS J, CUCULLO, LUCA · 2019 to 2021
$1.4M
NIDA NIH HHS R01 DA049737NINDS NIH HHS R01 NS046526NINDS NIH HHS R01 NS117906
6 · The paper itself

Abstract

The vascular system plays a critical role in human physiology and diseases. It is a complex subject to study using in vitro models due to its dynamic and three-dimensional microenvironment. Microfluidic technology has recently become a popular technology in various biological fields for its advantages in mimicking complex microenvironments to an extent not achievable by more conventional platforms. Microfluidic technologies can reproduce different vascular system-related structures and functions that can be utilized for drug development and human diseases studies. Herein, we first review the relevant structural and functional vascular biology systems of various organ systems and then the fabrication methods to reproduce these vascular districts. We provide a thorough review of the latest achievement in vascular organ-on-chip modeling specific to lung, heart, and the brain microvasculature for drug screening and the study of human disorders.

Indexed as

MicrofluidicsTissue EngineeringDrug DevelopmentHumansLungalternativeCell linesdrug developmentendotheliummicrofluidicpermeabilitypharmacokinetictissue

Identifiers

PMID35794768
PMCPMC10207903

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.