Evidence map›Paper›PMID 35794684›Full record

ReviewJournal of Zhejiang University. Science. B2022

Co-regulation of circadian clock genes and microRNAs in bone metabolism.

Tingting Li, Shihua Zhang, Yuxuan Yang, Lingli Zhang, Yu Yuan, Jun Zou

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Zhejiang University. Science. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  7. Article
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  9. Article
  10. Circular RNAs: typical biomarkers for bone-related diseases.Journal of Zhejiang University. Science. B · 2022
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Tingting LiSchool of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China.
Shihua ZhangCollege of Graduate Education, Jinan Sport University, Jinan 250102, China.
Yuxuan YangSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Lingli ZhangSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China.
Yu YuanSchool of Exercise and Health, Guangzhou Sport University, Guangzhou 510500, China. junzou@sus.edu.cn, yuanyumail@126.com.
Jun ZouSchool of Kinesiology, Shanghai University of Sport, Shanghai 200438, China. junzou@sus.edu.cn.
Shanghai University of Sport · CNGuangzhou Sport University · CNShandong Sport University · CN

Funding

Guangdong Provincial Natural Science Foundation of China No. 2022A1515010379National Natural Science Foundation of China Nos. 81901430 and 81871835Shanghai Frontiers Science Research Base of Exercise and Metabolic Health, and the Shanghai Key Laboratory for Human Athletic Ability Development and Support (Shanghai University of Sport) No. 11DZ2261100the Innovation Project from Department of Education of Guangdong Province No. 2021KTSCX055
6 · The paper itself

Abstract

Mammalian bone is constantly metabolized from the embryonic stage, and the maintenance of bone health depends on the dynamic balance between bone resorption and bone formation, mediated by osteoclasts and osteoblasts. It is widely recognized that circadian clock genes can regulate bone metabolism. In recent years, the regulation of bone metabolism by non-coding RNAs has become a hotspot of research. MicroRNAs can participate in bone catabolism and anabolism by targeting key factors related to bone metabolism, including circadian clock genes. However, research in this field has been conducted only in recent years and the mechanisms involved are not yet well established. Recent studies have focused on how to target circadian clock genes to treat some diseases, such as autoimmune diseases, but few have focused on the co-regulation of circadian clock genes and microRNAs in bone metabolic diseases. Therefore, in this paper we review the progress of research on the co-regulation of bone metabolism by circadian clock genes and microRNAs, aiming to provide new ideas for the prevention and treatment of bone metabolic diseases such as osteoporosis.

Indexed as

Circadian ClocksMicroRNAsOsteoporosisAnimalsCircadian RhythmMammalsOsteogenesisMicroRNAsBone metabolismCircadian clock geneCircadian rhythmMicroRNAs

Identifiers

PMID35794684
PMCPMC9264112
OpenAlexW4284897321

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.