Evidence map›Paper›PMID 35794602›Full record

ArticleJournal of nanobiotechnology2022

A universal strategy for the fabrication of single-photon and multiphoton NIR nanoparticles by loading organic dyes into water-soluble polymer nanosponges.

Li-Xing Yang, Yu-Cheng Liu, Chang-Hui Cho, Yi-Rou Chen, Chan-Shan Yang, Yin-Lin Lu, Zhiming Zhang, Yi-Tseng Tsai, Yu-Cheng Chin, Jiashing Yu and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 9 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 6 institutions in 2 countries.

Li-Xing Yang *Department of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan.
Yu-Cheng Liu *Institute of Translational Medicine, Faculty of Health Sciences & Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macao SAR, 999078, China.
Chang-Hui Cho *Department of Chemistry, Tunghai University, Taichung, 40704, Taiwan.
Yi-Rou Chen *Department of Chemistry, Tamkang University, 25137, New Taipei City, Taiwan.
Chan-Shan Yang *Institute and Undergraduate Program of Electro-Optical Engineering, National Taiwan Normal University, Taipei, 11677, Taiwan.
Yin-Lin LuInstitute of Translational Medicine, Faculty of Health Sciences & Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macao SAR, 999078, China.
Zhiming ZhangInstitute of Translational Medicine, Faculty of Health Sciences & Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macao SAR, 999078, China.
Yi-Tseng TsaiDepartment of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan.
Yu-Cheng ChinDepartment of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan.
Jiashing YuDepartment of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan.
Hsiu-Min PanDepartment of Chemistry, Tamkang University, 25137, New Taipei City, Taiwan.
Wei-Rou JiangDepartment of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan.
Zi-Chun ChiaDepartment of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan.
Wei-Shiang HuangDepartment of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan.
Yu-Lin ChiuDepartment of Chemistry, Tunghai University, Taichung, 40704, Taiwan.
Chun-Kai SunDepartment of Chemical Engineering, National Taiwan University, Taipei, 106, Taiwan.
Yu-Ting HuangDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Li-Ming ChenDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Ken-Tsung WongDepartment of Chemistry, National Taiwan University, Taipei, 10617, Taiwan.
Han-Min HuangInstitute and Undergraduate Program of Electro-Optical Engineering, National Taiwan Normal University, Taipei, 11677, Taiwan.
Chih-Hsin ChenDepartment of Chemistry, Tamkang University, 25137, New Taipei City, Taiwan. chc@mail.tku.edu.tw.
Yuan Jay ChangDepartment of Chemistry, Tunghai University, Taichung, 40704, Taiwan. jaychang@thu.edu.tw.
Chih-Chia HuangDepartment of Photonics, National Cheng Kung University, Tainan, 70101, Taiwan. c2huang@mail.ncku.edu.tw.
Tzu-Ming LiuInstitute of Translational Medicine, Faculty of Health Sciences & Ministry of Education Frontiers Science Center for Precision Oncology, University of Macau, Macao SAR, 999078, China. tmliu@umac.mo.
National Cheng Kung University · TWNational Taiwan University · TWUniversity of Macau · MOTamkang University · TWTunghai University · TWNational Taiwan Normal University · TW

Funding

Faculty of Health Sciences, University of Macau, the internal funding of the University of Macau MYRG2018-00070-FHSMinistry of Science and Technology, Taiwan MOST 107-2113-M-002-019-MY3Ministry of Science and Technology, Taiwan MOST 108-2113-M-006-012-MY3Ministry of Science and Technology, Taiwan MOST 109-2113-M-029-009Ministry of Science and Technology, Taiwan MOST 109-2113-M-032-002Ministry of Science and Technology, Taiwan MOST 110-2112-M-003-012-MY3Ministry of Science and Technology, Taiwan MOST 110-2221-E-002-013The Science and Technology Development Fund, Macau SAR 122/2016/A3
6 · The paper itself

Abstract

The development of optical organic nanoparticles (NPs) is desirable and widely studied. However, most organic dyes are water-insoluble such that the derivatization and modification of these dyes are difficult. Herein, we demonstrated a simple platform for the fabrication of organic NPs designed with emissive properties by loading ten different organic dyes (molar masses of 479.1-1081.7 g/mol) into water-soluble polymer nanosponges composed of poly(styrene-alt-maleic acid) (PSMA). The result showed a substantial improvement over the loading of commercial dyes (3.7-50% loading) while preventing their spontaneous aggregation in aqueous solutions. This packaging strategy includes our newly synthesized organic dyes (> 85% loading) designed for OPVs (242), DSSCs (YI-1, YI-3, YI-8), and OLEDs (ADF-1-3, and DTDPTID) applications. These low-cytotoxicity organic NPs exhibited tunable fluorescence from visible to near-infrared (NIR) emission for cellular imaging and biological tracking in vivo. Moreover, PSMA NPs loaded with designed NIR-dyes were fabricated, and photodynamic therapy with these dye-loaded PSMA NPs for the photolysis of cancer cells was achieved when coupled with 808 nm laser excitation. Indeed, our work demonstrates a facile approach for increasing the biocompatibility and stability of organic dyes by loading them into water-soluble polymer-based carriers, providing a new perspective of organic optoelectronic materials in biomedical theranostic applications.

Indexed as

NanoparticlesPhotochemotherapyColoring AgentsPolymersWaterColoring AgentsPolymersWaterFluorescence imagingMultiphoton microscopyNear-infrared redOptoelectronic materialPhotodynamic therapyPolymerTheranostic

Identifiers

PMID35794602
PMCPMC9258130
OpenAlexW4283835100

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.