ArticleBMC nephrology2022
High prevalence of chronic kidney disease of unknown etiology among workers in the Mesoamerican Nephropathy Occupational Study.
Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Environmental risk factors for chronic kidney disease of non-traditional causes in tropical coastal areas: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Kidney health among adolescents living in a high-risk region for CKDu.BMC nephrology · 2026Article
- Urine glyphosate levels and kidney function outcomes in a cohort study of workers in El Salvador and Nicaragua.Journal of exposure science & environmental epidemiology · 2026Article
- Scoping Review of Interventions to Prevent CKD of Unknown Origin in Working Populations.Kidney international reports · 2026Article
- Occupational heat exposure and chronic kidney disease risk under climate warming: a retrospective cohort study of petrochemical workers with mechanistic insights.Environmental health : a global access science source · 2026Article
- The Association of Arsenic Metabolism and Blood Pressure: A Cross-Sectional Analysis in the MesoAmerican Nephropathy Occupational Study (MANOS).Research square · 2026Article
- Case-control study of water and agricultural exposures among women in CKDu-endemic Sri Lanka.Journal of water and health · 2026Article
- Mesoamerican nephropathy: A silent epidemic at the nexus of climate, labor, and health.AIMS public health · 2026Article
- Longitudinal Estimated GFR Trajectories Among Workers at High Risk for CKD of Unknown Etiology.Kidney international reports · 2025Article
- Rationale and Design of the International Prospective Study of CKD of Uncertain Etiology in Agricultural Communities.Kidney international reports · 2025Article
- Heat Stress and Determinants of Kidney Health Among Agricultural Workers in the United States: An Integrative Review.International journal of environmental research and public health · 2025Review
- Environmental exposure assessment in the international prospective study of Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) research consortium: Design and protocol development.The Science of the total environment · 2025Article
- A Systems-Based Approach for the Prevention of Heat-Associated Kidney Disease in Latin American Workers.Annals of global health · 2025Article
- Genetic risk factors for Mesoamerican nephropathy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- International prevalence patterns of low eGFR in adults aged 18-60 without traditional risk factors from population-based cross-sectional studies: a disadvantaged populations eGFR epidemiology (DEGREE) study.medRxiv : the preprint server for health sciences · 2024Article
- Concurrent Particulate Matter and Heat Exposure in Working and Non-working Women in Rural Guatemala.Atmosphere · 2024Article
- Ethical considerations for genetic research in low-income countries: perceptions of informed consent, data sharing, and expectations in Nicaragua.European journal of human genetics : EJHG · 2024Article
- Article
- [Quantification of the burden of chronic kidney disease in Latin America: an invisible epidemicQuantificação da carga da doença renal crônica na América Latina: uma epidemia invisível].Revista panamericana de salud publica = Pan American journal of public health · 2024Article
- The impact of heat exposures on biomarkers of AKI and plasma metabolome among agricultural and non-agricultural workers.Environment international · 2023Article
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundMortality from chronic kidney disease of unknown etiology (CKDu) is extremely high along the Pacific coast of Central America, particularly among sugarcane workers. The Mesoamerican Nephropathy Occupational Study (MANOS) is a prospective cohort study of CKDu among agricultural and non-agricultural workers in El Salvador and Nicaragua. The objective of this manuscript is to describe the MANOS cohort recruitment, baseline data collection, and CKDu prevalence after two rounds.
methodsWorkers with no known diabetes, hypertension, or CKD were recruited from sugarcane, corn, plantain, brickmaking, and road construction industries (n = 569). Investigators administered questionnaires, collected biological samples, and observed workers for three consecutive workdays at the worksite. Serum specimens were analyzed for kidney function parameters, and used to calculate estimated glomerular filtration rate (eGFR). At six months, serum was collected again prior to the work shift. CKD at baseline is defined as eGFR ≤ 60 ml/min/1.73m
resultsPrevalence of CKD at baseline was 7.4% (n = 42). Age-standardized prevalence was highest in Salvadoran sugarcane (14.1%), followed by Salvadoran corn (11.6%), and Nicaraguan brickmaking (8.1%). Nicaraguan sugarcane had the lowest prevalence, likely due to kidney function screenings prior to employment.
conclusionDespite efforts to enroll participants without CKD, our identification of prevalent CKD among agricultural and non-agricultural workers in the MANOS cohort indicates notable kidney disease in the region, particularly among sugarcane workers.
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