SynthesisBMC geriatrics2022
Early use of probiotics might prevent antibiotic-associated diarrhea in elderly (>65 years): a systematic review and meta-analysis.
Synthesis in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 40 citations in OpenAlex.
- Oral antibiotics prescribing patterns and associated diarrhea risk: Public health implications.Journal of public health research · 2026Article
- Three Characterized Probiotics from Dairy Sources-Weissella confusa (ProY 5.1), Enterococcus lactis (ProY 5.3), and Leuconostoc lactis (RM 2.1)-Exhibit Potential for Antidiarrheal Effects.Probiotics and antimicrobial proteins · 2026Article
- The Regulating Effect of Weizmannia coagulans BC-G44 on Antibiotic-Associated Diarrhea and its Improvement on Gut Microbiota.Probiotics and antimicrobial proteins · 2026Article
- From Probiotics to Postbiotics-An Update on Their Biotherapeutic Potential and the Emerging Strategies in Human Health.International journal of molecular sciences · 2026Review
- Next-Generation Microencapsulation Technologies for Probiotic Protection and Precision Delivery.Microbial biotechnology · 2026Review
- Nanobiotic-Enhanced Probiotics for Targeted Gut Delivery: Mechanisms, Therapeutic Applications, and Translational Challenges.International journal of nanomedicine · 2026Review
- Article
- Review
- Primary care and specialist physicians' prescribing preferences for concurrent probiotic-antibiotic therapy: a multinational clinical practice survey across 13 countries.Frontiers in medicine · 2025Article
- Probiotic use reduces the incidence of antibiotic-associated diarrhea among adult patients: a meta-analysis.Przeglad gastroenterologiczny · 2025Review
- Akkermansia muciniphila Protects Against Antibiotic-Associated Diarrhea in Mice.Probiotics and antimicrobial proteins · 2024Article
- Is There Evidence to Support Probiotic Use for Healthy People?Advances in nutrition (Bethesda, Md.) · 2024Review
- Interpretable machine learning models for predicting the incidence of antibiotic- associated diarrhea in elderly ICU patients.BMC geriatrics · 2024Article
- Prebiotics and Probiotics for Gastrointestinal Disorders.Nutrients · 2024Review
- Effect of probiotic yogurt on antibiotic-associated diarrhea among pediatric patients; randomized controlled trial.Journal of education and health promotion · 2024Article
- Glycyrol targets Pneumolysin (PLY) oligomerization to reduceFrontiers in pharmacology · 2024Article
- Effects ofNutrients · 2023Article
- Egg White and Yolk Protein Atlas: New Protein Insights of a Global Landmark Food.Foods (Basel, Switzerland) · 2023Article
- Potentially inappropriate prescriptions of antibiotics in geriatric psychiatry-a retrospective cohort study.Frontiers in psychiatry · 2023Article
- Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAntibiotic-associated diarrhea (AAD) is diarrhea associated with consuming antibiotics that cannot be explained by other causes. AAD prolongs admission time and increases mortality and financial costs. Elderly individuals are more prone to receive antibiotic treatment and develop AAD. The finding that living probiotic microorganisms decrease AAD incidence in adults (<65 years) has been clarified. However, it is controversial among elderly individuals.
methodsWe aimed to explore whether probiotics could prevent AAD in elderly individuals. We searched three electronic databases (PubMed, EMBASE, and The Cochrane Library), and two reviewers independently screened and assessed the studies. RevMan5.4 software was used to perform a meta-analysis according to the PRISMA guidelines.
resultsEight RCTs of 4691 participants were included. We excluded two large studies because probiotics were used 48 hours after the first dose of antibiotics, and there was no effect. Subgroup analysis of 6 RCTs showed that probiotics given within two days of antibiotic treatment produced a lower AAD prevalence rate in elderly individuals.
conclusionWe recommend that elderly individuals could be routinely distributed probiotics to prevent AAD development when receiving antibiotic treatment.
trial registrationThe review was not registered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.