Evidence map›Paper›PMID 35794500›Full record

SynthesisSurgical endoscopy2022

Selective intraoperative cholangiography should be considered over routine intraoperative cholangiography during cholecystectomy: a systematic review and meta-analysis.

Norbert Kovács, Dávid Németh, Mária Földi, Bernadette Nagy, Stefania Bunduc, Péter Hegyi, Judit Bajor, Katalin Eszter Müller, Áron Vincze, Bálint Erőss and 1 more

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. A History of Cholecystectomy.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2026
    Article
  8. Prevention of bile duct injury - A bird's eye view.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
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  11. Observational
  12. Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Norbert KovácsDoctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.
Dávid NémethInstitute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.
Mária FöldiDoctoral School of Clinical Medicine, University of Szeged, Szeged, Hungary.
Bernadette NagyInstitute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.
Stefania BunducInstitute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.
Péter HegyiInstitute for Translational Medicine, Szentágothai Research Centre, University of Pécs Medical School, Pécs, Hungary.
Judit BajorDivision of Gastroenterology, First Department of Medicine, University of Pécs Medical School, Pécs, Hungary.
Katalin Eszter MüllerInstitute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.
Áron VinczeDivision of Gastroenterology, First Department of Medicine, University of Pécs Medical School, Pécs, Hungary.
Bálint ErőssInstitute for Translational Medicine, University of Pécs Medical School, Pécs, Hungary.
Szabolcs ÁbrahámDepartment of Surgery, Szent-Györgyi Albert Medical and Pharmaceutical Centre, University of Szeged, Semmelweis u. 8, 6720, Szeged, Hungary. abraham.szabolcs@med.u-szeged.hu.ORCID http://orcid.org/0000-0002-2191-1714

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDecades of debate surround the use of intraoperative cholangiography (IOC) during cholecystectomy. To the present day, the role of IOC is controversial as regards decreasing the rate of bile duct injury (BDI). We aimed to review and analyse the available literature on the benefits of IOC during cholecystectomy.

methodsA systematic literature search was performed until 19 October 2020 in five databases using the following search keys: cholangiogra* and cholecystectomy. The primary outcomes were BDI and retained stone rate. To investigate the differences between the groups (routine IOC vs selective IOC and IOC vs no IOC), we calculated weighted mean differences (WMD) for continuous outcomes and relative risks (RR) for dichotomous outcomes, with 95% confidence intervals (CI).

resultsOf the 19,863 articles, 38 were selected and 32 were included in the quantitative synthesis. Routine IOC showed no superiority compared to selective IOC in decreasing BDI (RR = 0.91, 95% CI 0.66; 1.24). Comparing IOC and no IOC, no statistically significant differences were found in the case of BDI, retained stone rate, readmission rate, and length of hospital stay. We found an increased risk of conversion rate to open surgery in the no IOC group (RR = 0.64, CI 0.51; 0.78). The operation time was significantly longer in the IOC group compared to the no IOC group (WMD = 11.25 min, 95% CI 6.57; 15.93).

conclusionOur findings suggest that IOC may not be indicated in every case, however, the evidence is very uncertain. Further good quality research is required to address this question.

Indexed as

Bile Duct DiseasesCholecystectomy, LaparoscopicCholangiographyCholecystectomyHumansIntraoperative CareLength of StayBDIBile duct injuryCholangiographyCholecystectomyIOCLaparoscopic cholecystectomy

Identifiers

PMID35794500
PMCPMC9485186

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.