Evidence map›Paper›PMID 35794482›Full record

ArticleNature2022

Single-cell roadmap of human gonadal development.

Luz Garcia-Alonso, Valentina Lorenzi, Cecilia Icoresi Mazzeo, João Pedro Alves-Lopes, Kenny Roberts, Carmen Sancho-Serra, Justin Engelbert, Magda Marečková, Wolfram H Gruhn, Rachel A Botting and 12 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 271 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
271citing papers in PubMed, 1 pooled it
39.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

271 citing papers in PubMed, 1 synthesis or guideline pooled it, 455 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Spatiotemporally primed coelomic epithelium and supporting-like cells establish the dual origin of granulosa cells.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. celltypeEnrich: a consensus-based scRNA-seq cluster annotation tool.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review

211 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 6 institutions in 2 countries.

Luz Garcia-Alonso *Wellcome Sanger Institute, Cambridge, UK.
Valentina Lorenzi *Wellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-3111-4006
Cecilia Icoresi MazzeoWellcome Sanger Institute, Cambridge, UK.
João Pedro Alves-LopesWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Kenny RobertsWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-6155-0821
Carmen Sancho-SerraWellcome Sanger Institute, Cambridge, UK.
Justin EngelbertBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Magda MarečkováWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-4897-5013
Wolfram H GruhnWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-6072-1916
Rachel A BottingBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.ORCID http://orcid.org/0000-0001-9595-4605
Tong LiWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-8240-4476
Berta CrespoGreat Ormond Street Institute of Child Health, University College London, London, UK.ORCID http://orcid.org/0000-0003-0006-009X
Stijn van DongenWellcome Sanger Institute, Cambridge, UK.
Vladimir Yu KiselevWellcome Sanger Institute, Cambridge, UK.
Elena PrigmoreWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-8870-0316
Mary HerbertBiosciences Institute, Newcastle University, Newcastle upon Tyne, UK.
Ashley MoffettUniversity of Cambridge Centre for Trophoblast Research, Department of Pathology, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-8388-9073
Alain ChédotalSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France.ORCID http://orcid.org/0000-0001-7577-3794
Omer Ali BayraktarWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0001-6055-277X
Azim SuraniWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
Muzlifah HaniffaWellcome Sanger Institute, Cambridge, UK.
Roser Vento-TormoWellcome Sanger Institute, Cambridge, UK. rv4@sanger.ac.uk.ORCID http://orcid.org/0000-0002-9870-8474
Wellcome Sanger Institute · GBNewcastle University · GBUniversity of Cambridge · GBCentre National de la Recherche Scientifique · FRGreat Ormond Street Hospital · GBWellcome/MRC Cambridge Stem Cell Institute · GB

Funding

Medical Research Council MR/R006237/1Medical Research Council MR/S036350/1Medical Research Council R006237/1Wellcome TrustWellcome Trust 206194Wellcome Trust 836291
6 · The paper itself

Abstract

Gonadal development is a complex process that involves sex determination followed by divergent maturation into either testes or ovaries

Indexed as

Cell LineageGerm CellsOvarySex DifferentiationSingle-Cell AnalysisTestisAnimalsChromatinFemaleGranulosa CellsHumansImmunoglobulinsMacrophagesMaleMembrane GlycoproteinsMembrane ProteinsChromatinImmunoglobulinsMembrane GlycoproteinsMembrane ProteinsPAX8 protein, humanPax8 protein, mousePAX8 Transcription FactorReceptors, ImmunologicSIGLEC15 protein, humanTREM2 protein, human

Identifiers

PMID35794482
PMCPMC9300467
OpenAlexW4284885575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.