ArticleNature2022
C. elegans as a model for inter-individual variation in metabolism.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
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- Non-Mammalian Models for Mitochondria Research in CNS Disorders.Biomolecules · 2026Review
- A lipid-sensitive food choice behavior influences aging outcomes from a longevity-promoting diet.The FEBS journal · 2026Article
- Nematode-trapping fungus Arthrobotrys oligospora is hungry for iron-chelating agent COQ7 of nematodes.Natural products and bioprospecting · 2026Article
- Zinc excess promotes lysosome remodeling by activating HLH-30/TFEB through the action of the high zinc sensor HIZR-1.bioRxiv : the preprint server for biology · 2026Article
- Cycloastragenol Improves Fatty Acid Metabolism Through NHR-49/FAT-7 Suppression and Potent AAK-2 Activation inInternational journal of molecular sciences · 2026Article
- Apiin Promotes Healthy Aging inInternational journal of molecular sciences · 2025Article
- Comprehensive study of W06A7.4 and TMEM144 mediated pathways in aging: insights from Caenorhabditis elegans to human.Molecular genetics and genomics : MGG · 2025Article
- Biallelic variants in BBOX1 cause L-Carnitine deficiency and elevated γ-butyrobetaine.NPJ genomic medicine · 2025Article
- Nematode Pheromones as Key Mediators of Behavior, Development, and Ecological Interactions.Biomolecules · 2025Review
- Charting unknown metabolic reactions by mass spectrometry-resolved stable-isotope tracing metabolomics.Nature communications · 2025Article
- Interactions Between Bacterivorous Nematodes and Bacteria Reduce NAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- MONITTR allows real-time imaging of transcription and endogenous proteins in C. elegans.The Journal of cell biology · 2025Article
- The many roads toJournal of biosciences · 2025Review
- Annotation of Metabolites in Stable Isotope Tracing Untargeted Metabolomics via Khipu-web.Journal of the American Society for Mass Spectrometry · 2024Article
- Robustness and variability inbioRxiv : the preprint server for biology · 2024Article
- Host-microbe interactions rewire metabolism in a C. elegans model of leucine breakdown deficiency.Nature metabolism · 2024Article
- The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors.Nature microbiology · 2024Article
- C. elegans foraging as a model for understanding the neuronal basis of decision-making.Cellular and molecular life sciences : CMLS · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Bennett W FoxBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0002-9749-3491
Olga Ponomarova *Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Yong-Uk Lee *Department of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Gaotian Zhang *Department of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0001-6468-1341
Gabrielle E GieseDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Melissa WalkerDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Nicole M RobertoDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
Huimin NaDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Pedro R RodriguesBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Brian J CurtisBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.
Aiden R KolodziejBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA.ORCID http://orcid.org/0000-0003-0745-1157
Timothy A CrombieDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.ORCID http://orcid.org/0000-0002-5645-4154
Stefan ZdraljevicDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA.
L Safak YilmazDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Erik C AndersenDepartment of Molecular Biosciences, Northwestern University, Evanston, IL, USA. erik.andersen@northwestern.edu.ORCID http://orcid.org/0000-0003-0229-9651
Frank C SchroederBoyce Thompson Institute and Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY, USA. schroeder@cornell.edu.ORCID http://orcid.org/0000-0002-4420-0237
Albertha J M WalhoutDepartment of Systems Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. marian.walhout@umassmed.edu.ORCID http://orcid.org/0000-0001-5587-3608
University of Massachusetts Chan Medical School · USCornell University · USNorthwestern University · US
Funding
Large scale nutrigenetics and genomics in a tractable metazoan modelR01DK115690 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ANDERSEN, ERIK CHRISTIAN, SCHROEDER, FRANK CLEMENS · 2017 to 2020
$2.8MNIDDK NIH HHS R01 DK115690
Abstract
Individuals can exhibit differences in metabolism that are caused by the interplay of genetic background, nutritional input, microbiota and other environmental factors
Indexed as
Caenorhabditis elegansMetabolic Networks and PathwaysAlcohol OxidoreductasesAmino AcidsAnimalsCaenorhabditis elegans ProteinsHumansLactic AcidMitochondrial ProteinsModels, AnimalPropionatesVitamin B 12Alcohol OxidoreductasesAmino AcidsCaenorhabditis elegans Proteinshphd-1 protein, C eleganshydracrylic acidhydroxyacid-oxoacid transhydrogenaseLactic AcidMitochondrial ProteinsPropionatesVitamin B 12
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.