Evidence map›Paper›PMID 35794469›Full record

ArticleGene therapy2023

Selective attachment of a microtubule interacting peptide to plasmid DNA via a triplex forming oligonucleotide for transfection improvement.

Caroline Girardin, Delphine Maze, Cristine Gonçalves, Yann Thierry Le Guen, Kevin Pluchon, Chantal Pichon, Tristan Montier, Patrick Midoux

Abstract read
PubMed Publisher
In one paragraph

Article in Gene therapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Caroline GirardinCentre de Biophysique Moléculaire, CNRS UPR4301, Inserm and University of Orléans, 45071, Orléans cedex 02, France.
Delphine MazeCentre de Biophysique Moléculaire, CNRS UPR4301, Inserm and University of Orléans, 45071, Orléans cedex 02, France.
Cristine GonçalvesCentre de Biophysique Moléculaire, CNRS UPR4301, Inserm and University of Orléans, 45071, Orléans cedex 02, France.
Yann Thierry Le GuenUniv Brest, INSERM, EFS, UMR 1078, GGB - GTCA Team, F-29200, Brest, France.
Kevin PluchonUniv Brest, INSERM, EFS, UMR 1078, GGB - GTCA Team, F-29200, Brest, France.
Chantal PichonCentre de Biophysique Moléculaire, CNRS UPR4301, Inserm and University of Orléans, 45071, Orléans cedex 02, France.ORCID 0000-0003-3161-3937
Tristan MontierUniv Brest, INSERM, EFS, UMR 1078, GGB - GTCA Team, F-29200, Brest, France. Tristan.Montier@univ-brest.fr.ORCID 0000-0003-0452-6395
Patrick MidouxCentre de Biophysique Moléculaire, CNRS UPR4301, Inserm and University of Orléans, 45071, Orléans cedex 02, France. patrick.midoux@cnrs.fr.ORCID 0000-0002-8762-366X
Université d'Orléans · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In nonviral gene therapy approaches, the linkage of signal molecules to plasmid DNA (pDNA) is of interest for guiding its delivery to the nucleus. Here, we report its linkage to a peptide (P

Indexed as

DNAOligonucleotidesAnimalsMiceMicrotubulesPeptidesPlasmidsTransfectionDNAOligonucleotidesPeptides

Identifiers

PMID35794469
OpenAlexW4284882610

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.