Evidence map›Paper›PMID 35794345›Full record

ArticleMedical & biological engineering & computing2022

Investigation of tracer gas transport in a new numerical model of lung acini.

Christoph Schmidt, Christoph Joppek, Frederik Trinkmann, Ralf Takors, Giorgio Cattaneo, Johannes Port

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical & biological engineering & computing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christoph SchmidtInstitute of Biomedical Engineering, University of Stuttgart, Seidenstraße 36, 70174, Stuttgart, Germany. cs@bmt.uni-stuttgart.de.ORCID http://orcid.org/0000-0002-1487-7829
Christoph JoppekInstitute of Biomedical Engineering, University of Stuttgart, Seidenstraße 36, 70174, Stuttgart, Germany.
Frederik TrinkmannPneumology and Critical Care Medicine, Thoraxklinik at University Hospital Heidelberg, Translational Lung Research Center Heidelberg (TLRC), Member of German Center for Lung Research (DZL), Heidelberg, Germany.
Ralf TakorsInstitute of Biochemical Engineering, University of Stuttgart, Stuttgart, Germany.
Giorgio CattaneoInstitute of Biomedical Engineering, University of Stuttgart, Seidenstraße 36, 70174, Stuttgart, Germany.
Johannes PortInstitute of Biomedical Engineering, University of Stuttgart, Seidenstraße 36, 70174, Stuttgart, Germany.
University of Stuttgart · DEHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obstructive pulmonary diseases are associated with considerable morbidity. For an early diagnosis of these diseases, inert gas washouts can potentially be used. However, the complex interaction between lung anatomy and gas transport mechanisms complicates data analysis. In order to investigate this interaction, a numerical model, based on the finite difference method, consisting of two lung units connected in parallel, was developed to simulate the tracer gas transport within the human acinus. Firstly, the geometries of the units were varied and the diffusion coefficients (D) were kept constant. Secondly, D was changed and the geometry was kept constant. Furthermore, simple monoexponential growth functions were applied to evaluate the simulated data. In 109 of the 112 analyzed curves, monoexponential function matched simulated data with an accuracy of over 90%, potentially representing a suitable numerical tool to predict transport processes in further model extensions. For total flows greater than 5 × 10

Indexed as

LungModels, BiologicalGasesHumansGasesAcinar modelConvectionDiffusionGas distributionSingle branch-point model

Identifiers

PMID35794345
PMCPMC9365752
OpenAlexW4284897829

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.