Evidence map›Paper›PMID 35794252›Full record

ArticlePediatric research2023

Maternal acetaminophen use and cognitive development at 4 years: the Ontario Birth Study.

Jennifer M Lye, Julia A Knight, Jasleen Arneja, Ryan A Seeto, Jody Wong, Nadya Adel Khani, Jennifer D Brooks, Robert D Levitan, Stephen G Matthews, Stephen J Lye and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Jennifer M LyeProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada.
Julia A KnightProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada.
Jasleen ArnejaDivision of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Ryan A SeetoLunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada.
Jody WongProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada.
Nadya Adel KhaniProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada.
Jennifer D BrooksDivision of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
Robert D LevitanDepartment of Physiology, University of Toronto, Toronto, ON, Canada.
Stephen G MatthewsLunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada.
Stephen J LyeLunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada.
Rayjean J HungProsserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute of Sinai Health, Toronto, ON, Canada. rayjean.hung@lunenfeld.ca.
Lunenfeld-Tanenbaum Research Institute · CAUniversity of Toronto · CAPublic Health Ontario · CAMount Sinai Hospital · CA

Funding

CIHR CU3 160313CIHR FDN 143262
6 · The paper itself

Abstract

backgroundStudies have suggested a link between prenatal maternal acetaminophen use and adverse developmental outcomes in children. However, there exists a knowledge gap regarding overall cognitive development and use of acetaminophen, especially concerning the timing of use in pregnancy. This study aimed to characterize the relationship between maternal acetaminophen use and cognitive development at 4 years.

methodsThis analysis included data collected throughout pregnancy and delivery from women in the Ontario Birth Study prospective cohort from 2013 to 2019 and from the NIH Toolbox Early Childhood Cognition battery administered to 4-year-old children between 2018 and 2021 (n = 436). The exposure was maternal acetaminophen use and the primary outcome was a cognition composite score. The relationship between exposure and outcome was determined using Poisson regression with a robust error variance.

resultsWe did not observe any association between maternal acetaminophen intake any time before or during pregnancy and low cognition composite score of offspring. The IRR of suboptimal overall cognition was 1.38 (0.78-2.45), 1.22 (0.67-2.22), 0.80 (0.44-1.47), and 1.56 (0.74-3.29) for maternal use of acetaminophen before, in early, late, or overall pregnancy, respectively.

conclusionCurrent data do not provide evidence to support a relationship of maternal acetaminophen use during pregnancy with adverse cognitive effects at 4 years. IMPACT: Acetaminophen use during pregnancy may influence the risk of child neurocognitive disorders, but there is conflicting evidence of its relationship to sub-clinical measures of cognitive development such as executive function. The study design allowed us to examine the role of timing of acetaminophen use in its relationship with cognitive development, based on a validated and standardized tablet-administered instrument for children, instead of a teacher or parent report. We did not observe a clear relationship between maternal acetaminophen use at different timepoints during pregnancy and child cognitive development.

Indexed as

AcetaminophenPrenatal Exposure Delayed EffectsChild, PreschoolCognitionFemaleHumansOntarioPregnancyProspective StudiesAcetaminophen

Identifiers

PMID35794252
PMCPMC9261144
OpenAlexW4284698104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.