ArticleNPJ primary care respiratory medicine2022
The Timed Up and Go test predicts frailty in patients with COPD.
Article in NPJ primary care respiratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The impact of frailty on clinical outcomes among individuals with COPD: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- Influence of an inspiratory muscle fatigue protocol on older adults on respiratory muscle strength, muscle oxygen saturation, and functional capacity: a randomized controlled trial.BMC geriatrics · 2024Trial
- TUG-Defined Mobility Impairment and Physical Performance in Adults with Type 2 Diabetes Mellitus.Journal of clinical medicine · 2026Article
- Database for Prevalence and Determinants of Frailty in the Elderly with Quantifying Functional Mobility.Scientific data · 2026Article
- Predictive Value of the COPD Assessment Test Combined with Five-Repetition Sit-to-Stand Test for Impaired Exercise Tolerance in Primary Care COPD Patients: A Comparative Study with Cardiopulmonary Exercise Testing.International journal of chronic obstructive pulmonary disease · 2026Article
- Article
- Are There Differences in Postural Control and Muscular Activity in Individuals with COPD and with and Without Sarcopenia?Advances in respiratory medicine · 2025Article
- Effect of a home-based physical rehabilitation program via virtual reality on the functional outcomes of frail older adults: a quasi-experimental study.Scientific reports · 2025Article
- Timed "up and go" to identify physically inactive individuals with interstitial lung disease.Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia · 2025Article
- Relationship between functional independence measure scores and timed up-and-go time in postoperative elderly patients with vertebral and hip fractures.Journal of physical therapy science · 2024Article
- 'Watkins' & 'Watkins2.0': Smart phone applications (Apps) for gait-assessment in normal pressure hydrocephalus and decompensated long-standing overt ventriculomegaly.Acta neurochirurgica · 2024Article
- Association between Physical Function, Mental Function and Frailty in Community-Dwelling Older Adults: A Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Respiratory Muscle Training and Its Impact on Balance and Gait in Patients with Severe COPD.Medicina (Kaunas, Lithuania) · 2024Article
- Review
- The Effect of Omega-3 Fatty Acids on Sarcopenia: Mechanism of Action and Potential Efficacy.Marine drugs · 2023Review
- Rehabilitation for People with Respiratory Disease and Frailty: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2023Article
- Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study.EClinicalMedicine · 2023Article
- Is Frailty Diagnosis Important in Patients with COPD? A Narrative Review of the Literature.International journal of environmental research and public health · 2023Review
- The Impact of Frailty Status on Pulmonary Function and Mortality in Older Patients with Chronic Obstructive Pulmonary Disease.The journal of nutrition, health & aging · 2023Observational
- The acceptability, practicality, implementation and efficacy of a physical and social activity intervention 'BreatheHappy' for people with long-term respiratory conditions: A feasibility study.Chronic respiratory diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Timed Up and Go (TUG) is a global measure of mobility and has the ability to detect frail individuals. Frail patients with chronic obstructive pulmonary disease (COPD) are usually undiagnosed. We hypothesised that the TUG would identify frail patients with COPD. Frailty was assessed in 520 patients diagnosed with COPD and 150 controls using a Comprehensive Geriatric Assessment questionnaire and frailty index (FI) was derived. The TUG was used to assess physical mobility. All participants were assessed for lung function and body composition. A ROC curve was used to identify how well TUG discriminates between frail and non-frail patients with COPD. The patients with COPD and controls were similar in age, sex and BMI but the patients with COPD were more frail, mean ± SD FI 0.16 ± 0.08 than controls 0.05 ± 0.03, P < 0.001. Frail patients with COPD had a greater TUG time (11.55 ± 4.03 s) compared to non-frail patients (9.2 ± 1.6 sec), after controlling for age and lung function (F = 15.94, P < 0.001), and both were greater than the controls (8.3 ± 1.2 sec), P < 0.001. The TUG discriminated between frail and non-frail patients with COPD with an area under the curve of 72 (95% CI: 67-76), and a diagnostic odds ratio of 2.67 (95% CI:1.5-4.6), P < 0.001. The TUG showed the ability to discriminate between frail and non-frail patients with COPD, independent of age and severity of the airflow obstruction. The TUG is a simple, easy and quick measure that could be easily applied in restricted settings to screen for frailty in COPD.
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