Evidence map›Paper›PMID 35794069›Full record

ArticleAnnals of surgery2023

Preoperative Plasma Tau-PT217 and Tau-PT181 Are Associated With Postoperative Delirium.

Feng Liang, Kathryn Baldyga, Qimin Quan, Ashok Khatri, Shawn Choi, Jeanine Wiener-Kronish, Oluwaseun Akeju, M Brandon Westover, Kathryn Cody, Yuan Shen and 2 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06366412 (Effect of Dexmedetomidine on Serum Tau-217 Protein as a Biomarker for Post-operative Cognitive Dysfunction in Elderly Patients.), which is not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 1 pooled it
9.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06366412 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Effect of Dexmedetomidine on Serum Tau-217 Protein as a Biomarker for Post-operative Cognitive Dysfunction in Elderly Patients.

TypeinterventionalSponsorMinia University HospitalRan2024 to 2026Enrolled94ConditionsCognitive ImpairmentArmsDexmedetomidine Hydrochloride, normal saline
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Feng LiangGeriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA.
Kathryn BaldygaGeriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA.
Qimin QuanNanoMosaic Inc., Woburn, MA.
Ashok KhatriEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Shawn ChoiEndocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Jeanine Wiener-KronishDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Oluwaseun AkejuDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
M Brandon WestoverDepartment of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Kathryn CodyDepartment of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA.
Yuan ShenGeriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA.
Edward R MarcantonioDepartment of Medicine, Divisions of General Medicine and Gerontology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA.
Zhongcong XieGeriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA.
Harvard University · USMassachusetts General Hospital · USBeth Israel Deaconess Medical Center · USShanghai Tenth People's Hospital · CN

Funding

Postoperative Delirium and Alzheimer's Disease Related DementiasR01AG062509 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2019 to 2023
$3.7M
Investigation of Sleep in the Intensive Care Unit (ICU-SLEEP)R01NS102190 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$3.2M
Big Data and Deep Learning for the Interictal-Ictal-Injury ContiuumR01NS107291 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI WESTOVER, MICHAEL BRANDON · 2018 to 2022
$2.8M
Establishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4M
General Anesthesia and Alzheimer's Disease NeuropathogenesisRF1AG070761 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2020 to 2020
$1.9M
Tau/pTau as Biomarkers of Anesthesia/Surgery-Associated Neurocognitive Outcomes in ChildrenR21HD098754 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI XIE, ZHONGCONG · 2019 to 2020
$478k
NIA NIH HHS R01 AG062509NIA NIH HHS RF1 AG070761NICHD NIH HHS R21 HD098754NINDS NIH HHS R01 NS102190NINDS NIH HHS R01 NS107291NINDS NIH HHS RF1 NS120947
6 · The paper itself

Abstract

objectiveThis study aims to identify blood biomarkers of postoperative delirium.

backgroundPhosphorylated tau at threonine 217 (Tau-PT217) and 181 (Tau-PT181) are new Alzheimer disease biomarkers. Postoperative delirium is associated with Alzheimer disease. We assessed associations between Tau-PT217 or Tau-PT181 and postoperative delirium.

methodsOf 491 patients (65 years old or older) who had a knee replacement, hip replacement, or laminectomy, 139 participants were eligible and included in the analysis. Presence and severity of postoperative delirium were assessed in the patients. Preoperative plasma concentrations of Tau-PT217 and Tau-PT181 were determined by a newly established Nanoneedle technology.

resultsOf 139 participants (73±6 years old, 55% female), 18 (13%) developed postoperative delirium. Participants who developed postoperative delirium had higher preoperative plasma concentrations of Tau-PT217 and Tau-PT181 than participants who did not. Preoperative plasma concentrations of Tau-PT217 or Tau-PT181 were independently associated with postoperative delirium after adjusting for age, education, and preoperative Mini-Mental State score [odds ratio (OR) per unit change in the biomarker: 2.05, 95% confidence interval (CI):1.61-2.62, P <0.001 for Tau-PT217; and OR: 4.12; 95% CI: 2.55--6.67, P <0.001 for Tau-PT181]. The areas under the receiver operating curve for predicting delirium were 0.969 (Tau-PT217) and 0.885 (Tau-PT181). The preoperative plasma concentrations of Tau-PT217 or Tau-PT181 were also associated with delirium severity [beta coefficient (β) per unit change in the biomarker: 0.14; 95% CI: 0.09-0.19, P <0.001 for Tau-PT217; and β: 0.41; 95% CI: 0.12-0.70, P =0.006 for Tau-PT181).

conclusionsPreoperative plasma concentrations of Tau-PT217 and Tau-PT181 were associated with postoperative delirium, with Tau-PT217 being a stronger indicator of postoperative delirium than Tau-PT181.

Indexed as

Alzheimer DiseaseDeliriumEmergence DeliriumAgedBiomarkersFemaleHumansMalePostoperative ComplicationsBiomarkers

Identifiers

PMID35794069
PMCPMC9875943
OpenAlexW4283833382

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.