ArticleNeurology2022
Association of Pace of Aging Measured by Blood-Based DNA Methylation With Age-Related Cognitive Impairment and Dementia.
Open access · hybridAbstract read
In one paragraph
Article in Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
15.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
99 citing papers in PubMed, 1 synthesis or guideline pooled it, 135 citations in OpenAlex.
- The aging epigenome: integrative analyses reveal intersection with Alzheimer's disease.GeroScience · 2026Pooled it
- Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial.Nature aging · 2023Trial
- Pilot Study of Second-Generation DNA Methylation Epigenetic Markers in Relation to Cognitive and Neuropsychiatric Symptoms in Older Adults.Journal of Alzheimer's disease : JAD · 2023Trial
- Epigenetic Clock Trajectories and Brain Health in Midlife.medRxiv : the preprint server for health sciences · 2026Article
- Maternal biological aging from pregnancy through four years postpartum with disrupted recovery by subsequent pregnancy.iScience · 2026Article
- Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Analysis of second-generation epigenetic clocks reveals further associations between disproportionate biological ageing and hippocampal volume.GeroScience · 2026Article
- From aging to Alzheimer's disease: concordant brain DNA methylation changes in late life.Genome medicine · 2026Article
- A lipidomic based metabolic age score for monitoring the effects of lifestyle and diet on metabolic disease risk.Research square · 2026Article
- Epigenetic Age and Resilience in the Framingham Heart Study.Neurology open access · 2026Article
- Epigenetic Aging Clocks Associate with Cognitive Status but Not Cognitive Decline: Evidence from the Parkinson's Progression Markers Initiative.medRxiv : the preprint server for health sciences · 2026Article
- From the lab to lifestyle: epigenetic clocks in personalized aging and health.Biogerontology · 2026Review
- Article
- Trauma exposure, PTSD, and methylation of the blood brain barrier claudin-5 gene.Psychoneuroendocrinology · 2026Article
- Mental health across the lifecourse as predictors of epigenetic aging from a longitudinal birth cohort in the United States.Journal of affective disorders · 2026Article
- OpenScientist: evaluating an open agentic AI co-scientist to accelerate biomedical discovery.medRxiv : the preprint server for health sciences · 2026Article
- Epigenetic Clocks of Biological Aging and Risk of Incident Mild Cognitive Impairment and Dementia: The Women's Health Initiative Memory Study.Aging cell · 2026Article
- Article
- Association of epigenetic age acceleration with MRI biomarkers of aging and Alzheimer's disease neurodegeneration.medRxiv : the preprint server for health sciences · 2026Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 2 countries.
Karen SugdenFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York. karen.sugden@duke.edu.ORCID 0000-0002-4076-5927
Avshalom CaspiFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0003-0082-4600
Maxwell L ElliottFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0003-1083-6277
Kyle J BourassaFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0001-9372-2309
Kartik ChamartiFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.
David L CorcoranFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0001-7460-9247
Ahmad R HaririFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.
Renate M HoutsFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0002-1518-2631
Meeraj KothariFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.
Stephen KritchevskyFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0003-3336-6781
George A KuchelFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0001-8387-7040
Jonathan S MillFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0003-1115-3224
Benjamin S WilliamsFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0003-3274-5317
Daniel W BelskyFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0001-5463-2212
Terrie E MoffittFrom the Department of Psychology and Neuroscience (K.S., A.C., M.L.E., K.C., A.R.H., R.M.H., B.S.W., T.E.M.), and Center for Genomic and Computational Biology (K.S., A.C., B.S.W., T.E.M.), Duke University, Durham, NC; Department of Psychiatry and Behavioral Sciences (A.C., T.E.M.), Duke University School of Medicine, Durham, NC; Social, Genetic, and Developmental Psychiatry Centre (A.C, T.E.M.), Institute of Psychiatry, Psychology, and Neuroscience, King's College London, UK. Center for the Study of Aging and Human Development (K.J.B.), Duke University, Durham, NC; Department of Genetics (D.L.C.), University of North Carolina School of Medicine, Chapel Hill; Butler Columbia Aging Center (M.K., D.W.B.), Columbia University, New York, New York; Sticht Center for Healthy Aging and Alzheimer's Prevention (S.K.), Wake Forest School of Medicine, Winston-Salem, NC; UConn Center on Aging (G.A.K.), University of Connecticut, Farmington, Connecticut, USA; College of Medicine and Health (J.S.M.), University of Exeter Medical School, Devon, UK; and Department of Epidemiology (D.W.B.), Columbia University Mailman School of Public Health, New York, New York.ORCID 0000-0002-8589-6760
Alzheimer's Disease Neuroimaging Initiative*
University of North Carolina at Chapel Hill · USDuke University · US
Funding
Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MWake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Laura D. Baker · 2021 to 2026
$24.3MTemporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3MQuantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6MIs mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5MBEHAVIOR AND PHYSIOLOGY IN AGINGT32AG000029 · NIA · DUKE UNIVERSITY · PI Maria Marquine · 1985 to 2026
$9.3MLong-term multi-omics follow-up of the CALERIE Trial to generate new knowledge for geroscienceR01AG061378 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Daniel Walker Belsky · 2019 to 2026
$2.9MValidating a 3rd-generation methylation measure of accelerated aging: DunedinPoAm4xR01AG073207 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2022 to 2025
$2.9MTraining in lifespan behavioral, social, and neuroscience research connecting early-life cognitive decline to late-life ADRDF99AG068432 · NIA · DUKE UNIVERSITY · PI ELLIOTT, MAXWELL LORENZ · 2020 to 2021
$72kTHE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–Medical Research Council MR/P005918/1NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NIA NIH HHS F99 AG068432NIA NIH HHS P30 AG072947NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG049789NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG061378NIA NIH HHS R01 AG073207NIA NIH HHS T32 AG000029NIA NIH HHS U01 AG024904
Abstract
BACKGROUND AND
objectivesDNA methylation algorithms are increasingly used to estimate biological aging; however, how these proposed measures of whole-organism biological aging relate to aging in the brain is not known. We used data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) and the Framingham Heart Study (FHS) Offspring Cohort to test the association between blood-based DNA methylation measures of biological aging and cognitive impairment and dementia in older adults.
methodsWe tested 3 "generations" of DNA methylation age algorithms (first generation: Horvath and Hannum clocks; second generation: PhenoAge and GrimAge; and third generation: DunedinPACE, Dunedin Pace of Aging Calculated from the Epigenome) against the following measures of cognitive impairment in ADNI: clinical diagnosis of dementia and mild cognitive impairment, scores on Alzheimer disease (AD) / Alzheimer disease and related dementias (ADRD) screening tests (Alzheimer's Disease Assessment Scale, Mini-Mental State Examination, and Montreal Cognitive Assessment), and scores on cognitive tests (Rey Auditory Verbal Learning Test, Logical Memory test, and Trail Making Test). In an independent replication in the FHS Offspring Cohort, we further tested the longitudinal association between the DNA methylation algorithms and the risk of developing dementia.
resultsIn ADNI ( DISCUSSION: Third-generation blood-based DNA methylation measures of aging could prove valuable for measuring differences between individuals in the rate at which they age and in their risk for cognitive decline, and for evaluating interventions to slow aging.
Indexed as
Alzheimer DiseaseCognitive DysfunctionAgedAgingDNA MethylationHumansNeuropsychological Tests
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