ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022
Chemogenetic Disconnection between the Orbitofrontal Cortex and the Rostromedial Caudate Nucleus Disrupts Motivational Control of Goal-Directed Action.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Orbitofrontal value dynamics and striatal population geometry during interruption of automatic behavior.Neuron · 2026Article
- Functional connectivity between the caudate nucleus and the frontal lobe and its association with executive functions in children and adolescents: a resting state fMRI study.Brain imaging and behavior · 2026Article
- Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders.Molecular psychiatry · 2026Review
- Clarifying the neural circuit mechanisms of spontaneous social behavior in macaques.Frontiers in neural circuits · 2026Article
- Article
- Chemogenetic Disruption of Monkey Perirhinal Neurons Projecting to the Rostromedial Caudate Impairs Associative Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A Functional Magnetic Resonance Imaging Investigation of Hot and Cool Executive Functions in Reward and Competition.Sensors (Basel, Switzerland) · 2025Article
- Unsupervised decomposition of natural monkey behavior into a sequence of motion motifs.Communications biology · 2024Article
- Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.Nature communications · 2024Article
- Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2024Review
- Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.bioRxiv : the preprint server for biology · 2023Article
- Multimodal Imaging for Validation and Optimization of Ion Channel-Based Chemogenetics in Nonhuman Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Efficient viral expression of a chemogenetic receptor in the old-world monkey amygdala.Current research in neurobiology · 2023Article
- Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
The orbitofrontal cortex (OFC) and its major downstream target within the basal ganglia-the rostromedial caudate nucleus (rmCD)-are involved in reward-value processing and goal-directed behavior. However, a causal contribution of the pathway linking these two structures to goal-directed behavior has not been established. Using the chemogenetic technology of designer receptors exclusively activated by designer drugs with a crossed inactivation design, we functionally and reversibly disrupted interactions between the OFC and rmCD in two male macaque monkeys. We injected an adeno-associated virus vector expressing an inhibitory designer receptor, hM4Di, into the OFC and contralateral rmCD, the expression of which was visualized
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.