Evidence map›Paper›PMID 35793909›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2022

Role of C3a as a Novel Regulator of 25(OH)D

Jennifer K Mulligan, Dianna Nord, Maria V Villanueva, Jeb Justice, Brian Lobo, Rodney J Schlosser, Carl Atkinson

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. What can we learn about chronic rhinosinusitis through mucus?Current opinion in otolaryngology & head and neck surgery · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jennifer K MulliganDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL.
Dianna NordDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL.ORCID 0000-0001-9120-4655
Maria V VillanuevaDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL.
Jeb JusticeDepartment of Otolaryngology, University of Florida, Gainesville, FL; and.
Brian LoboDepartment of Otolaryngology, University of Florida, Gainesville, FL; and.ORCID 0000-0003-1533-1665
Rodney J SchlosserDepartment of Otolaryngology, Medical University of South Carolina, Charleston, SC.ORCID 0000-0001-6480-0275
Carl AtkinsonDivision of Pulmonary, Critical Care & Sleep Medicine, Department of Medicine, University of Florida, Gainesville, FL; carl.atkinson@medicine.ufl.edu.
University of Florida · USMedical University of South Carolina · US

Funding

South Carolina Clinical & Translational Research Institute (SCTR)UL1TR001450 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T., FLUME, PATRICK A · 2015 to 2024
$41.1M
South Carolina Clinical & Translational Research Institute (SCTR)KL2TR001452 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MCRAE-CLARK, AIMEE L · 2015 to 2024
$5.9M
Role of Vitamin D Metabolism in CRSR01AI134698 · NIAID · UNIVERSITY OF FLORIDA · PI MULLIGAN, JENNIFER KONOPA · 2018 to 2022
$2.3M
Epithelial cell complement production in the pathogenesis of chronic rhinosinusitisR01AI144364 · NIAID · UNIVERSITY OF FLORIDA · PI ATKINSON, CARL, MULLIGAN, JENNIFER KONOPA · 2020 to 2025
$2.2M
NCATS NIH HHS KL2 TR001452NCATS NIH HHS UL1 TR001450NIAID NIH HHS R01 AI134698NIAID NIH HHS R01 AI144364
6 · The paper itself

Abstract

In patients with chronic rhinosinusitis with nasal polyps, primary human sinonasal epithelial cell (HSNEC) 1α-hydroxylase levels are reduced, as is their ability to metabolize 25-hydroxycholecalciferol [25(OH)D

Indexed as

CalcitriolNasal PolypsEpithelial CellsHumansMixed Function OxygenasesVitamin D1,25-dihydroxyvitamin D25-hydroxyvitamin DCalcitriolMixed Function OxygenasesVitamin D

Identifiers

PMID35793909
PMCPMC9432430
OpenAlexW4284895898

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.