Evidence map›Paper›PMID 35793858›Full record

ArticleBMJ case reports2022

Atezolizumab-induced autoimmune diabetes mellitus presenting as diabetic ketoacidosis and Takotsubo cardiomyopathy.

Sachi Singhal, Goonja Patel, Rohan Bir Singh, Aakash Goyal, Karen Avgush, Jean Koka

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Systemic therapies in hepatocellular carcinoma: A revolution?United European gastroenterology journal · 2024
    Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Sachi SinghalDepartment of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA.
Goonja PatelDepartment of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA.
Rohan Bir SinghDepartment of Ophthalmology, Harvard Medical School, Boston, MA, USA rohan_singh@meei.harvard.edu Jkoka@ahopc.com.ORCID http://orcid.org/0000-0002-2426-3900
Aakash GoyalDepartment of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA.
Karen AvgushDepartment of Internal Medicine, Crozer-Chester Medical Center, Upland, PA, USA.
Jean KokaDepartment of Hematology/Oncology, Crozer-Chester Medical Center, Upland, PA, USA rohan_singh@meei.harvard.edu Jkoka@ahopc.com.
Crozer-Keystone Health System · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atezolizumab is a humanised monoclonal IgG1 antibody that is used in treating many solid malignancies. Endocrinopathies are known but a rare adverse event of these immunotherapeutic drugs. Autoimmune diabetes induced by atezolizumab has been rarely reported in the literature. We report the case of a woman in her eighth decade with no known history of diabetes who developed new-onset autoimmune diabetes and Takotsubo cardiomyopathy due to the adverse effects of atezolizumab therapy for hepatocellular carcinoma. We also review the characteristics and outcomes of cases previously reported in the literature.

Indexed as

Diabetes Mellitus, Type 1Diabetic KetoacidosisLiver NeoplasmsTakotsubo CardiomyopathyAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedFemaleHumansAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedatezolizumabCardiovascular medicineDiabetesOncology

Identifiers

PMID35793858
PMCPMC9260801
OpenAlexW4284882657

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.