Evidence map›Paper›PMID 35793841›Full record

ArticleBMJ case reports2022

Intratympanic steroid treatments rescued recurrent hearing loss following COVID-19 vaccination and detection of an intralabyrinthine schwannoma.

Weihang Li, Alan Micco, Deyu Fang, Huiping Liu

Open access · hybridAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Weihang LiAeronautical & Astronautical Engineering, Purdue University, West Lafayette, Indiana, USA.
Alan MiccoOtolaryngology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Deyu FangPathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA huiping.liu@northwestern.edu fangd@northwestern.edu.
Huiping LiuPharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA huiping.liu@northwestern.edu fangd@northwestern.edu.ORCID http://orcid.org/0000-0003-4822-7995
Northwestern University · USPurdue University West Lafayette · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
Clinical analysis and therapeutic development of exosomal ACE2R01AI167272 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Deyu Fang, Huiping Liu · 2022 to 2026
$3.6M
NCATS NIH HHS UL1 TR001422
6 · The paper itself

Abstract

It remains unclear how to effectively treat rare cases of sudden and recurrent hearing losses which might coincidently follow vaccination. We report the first case, to our knowledge, of systemic and local steroid administration to successfully treat sudden and recurrent left-ear hearing loss, respectively, following a second dose of the BNT162b2 COVID-19 mRNA vaccination which inflammatory response potentially affected an existing left intralabyrinthine schwannoma in a young male patient. This case highlights the importance and timing of intratympanic steroid treatment strategies to suppress the progressive symptoms and restore hearing to a stable condition, and therefore avoid permanent hearing loss which would otherwise demand a surgical removal of the schwannoma to improve vertigo and reconstitute artificial hearing.

Indexed as

COVID-19DeafnessHearing Loss, SensorineuralHearing Loss, SuddenNeurilemmomaBNT162 VaccineCOVID-19 VaccinesHumansMaleSteroidsVaccinationBNT162 VaccineCOVID-19 VaccinesSteroidsEar, nose and throat/otolaryngologyOncologyVaccination/immunisation

Identifiers

PMID35793841
PMCPMC9260791
OpenAlexW4284898438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.