ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2022
Association between Body Mass Index and Risk of Gastric Cancer by Anatomic and Histologic Subtypes in Over 500,000 East and Southeast Asian Cohort Participants.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Body mass index and gastric cancer risk: results from the Stomach Cancer Pooling Project Consortium.International journal of epidemiology · 2025Pooled it
- Pooled it
- Mechanism of LPS-activated gingival fibroblasts promote the migration of gastric cancer cells via CXCL12/CXCR4-Snail2-EMT axis.In vitro cellular & developmental biology. Animal · 2026Article
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- Short-term outcomes of minimally invasive gastrectomy in population with obesity versus population without obesity: the obesity paradox.Updates in surgery · 2025Article
- Adiposity and risks of gastrointestinal cancers: A 10-year prospective study of 0.5 million Chinese adults.International journal of cancer · 2025Article
- Development and validation of a relatively accurate gastric cancer high-risk group screening scoring system in urban residents.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- Prevalence and factors associated with organic dyspepsia in older adults with dyspepsia.Scientific reports · 2025Article
- Risk Factors and Prevention of Stomach Cancer, ExcludingThe Korean journal of helicobacter and upper gastrointestinal research · 2024Review
- An analysis of the relationship of triglyceride glucose index with gastric cancer prognosis: A retrospective study.Cancer medicine · 2024Article
- Identification of phenomic data in the pathogenesis of cancers of the gastrointestinal (GI) tract in the UK biobank.Scientific reports · 2024Article
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- Ethnic-specific associations between body mass index and gastric cancer: a Mendelian randomization study in European and Korean populations.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Article
- Body mass index and esophageal and gastric cancer: A pooled analysis of 10 population-based cohort studies in Japan.Cancer science · 2023Article
- Gastric Cancer Risk in Association with Underweight, Overweight, and Obesity: A Systematic Review and Meta-Analysis.Cancers · 2023Review
- Cancer Progress and Priorities: Gastric Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2023Article
- Editorial: Obesity and gastrointestinal cancer.Frontiers in surgery · 2022Article
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37 authors at 20 institutions in 9 countries.
Funding
Abstract
backgroundThis study was performed to investigate the association between body mass index (BMI) and gastric cancer in East and Southeast Asia where most of gastric cancer is non-cardia gastric cancer.
methodsOn the basis of 8,997 gastric cancer cases among the Asia Cohort Consortium participants from China, Japan, Korea, and Singapore (N = 538,835), we assessed gastric cancer risk according to BMI by calculating hazard ratios (HR) and 95% confidence intervals (CI) using the Cox proportional hazard regression model.
resultsA U-shaped associations between BMI and gastric cancer risk were observed. Gastric cancer risks in underweight group (<18.5 kg/m2) and in obesity group (≥27.5 kg/m2) were higher than reference BMI group (23-24.9 kg/m2; HR, 1.15; 95% CI, 1.05-1.25 for underweight; HR, 1.12; 95% CI, 1.03-1.22 for obesity, respectively). The associations of underweight and obesity with gastric cancer risk were consistent in the analyses for non-cardia gastric cancer, intestinal-type gastric cancer, and late-onset gastric cancer. No significant association of underweight and obesity with the risk of cardia gastric cancer, diffuse-type gastric cancer, and early-onset gastric cancer was observed. In addition, we found that the U-shaped association between BMI and gastric cancer risk remained in nonsmokers, while only underweight was related to increased gastric cancer risk in smokers.
conclusionsBMI has a U-shaped association with gastric cancer risk in East and Southeast Asian population, especially for the non-cardia gastric cancer, intestinal-type gastric cancer, and late-onset gastric cancer. IMPACT: Future studies with consideration of anatomic location and histology of gastric cancer are needed to establish the association of underweight as well as obesity with gastric cancer risk.
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