ArticleJournal of the American Chemical Society2022
Precision Navigation of Hepatic Ischemia-Reperfusion Injury Guided by Lysosomal Viscosity-Activatable NIR-II Fluorescence.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 189 citations in OpenAlex.
- NIR-II photothermal-driven pulsatile PTH release for osteoporotic bone repair.National science review · 2026Article
- A dual-responsive fluorescent probe for imaging viscosity and polarity in nonalcoholic fatty liver disease.Smart molecules : open access · 2026Article
- Antiaromaticity-Based General Molecular Design of Activatable Near-Infrared Photoacoustic Probes with High Acoustic Loudness.Chemical & biomedical imaging · 2026Article
- Silicon Rhodamine-Based Fluorescence Lifetime Probe for Dynamics Mapping Lysosomal Oxidative Stress.Chemical & biomedical imaging · 2026Article
- A viscosity-activable nano-micelle with aggregation-induced emission for boosting NIR-II fluorescence imaging-guided synergetic photodynamic/photothermal therapy of breast cancer.Materials today. Bio · 2025Article
- An acceptor motor-driven electronic donor-acceptor supramolecular scaffold towards imaging-guided tumor therapy.Chemical science · 2025Article
- Breaking shackles of molecular weight and emission for NIR-II fluorophores by regulating Columb attraction interaction.Nature communications · 2025Article
- Tandem reaction-powered near-infrared fluorescent molecular reporter for real-time imaging of lung diseases.Chemical science · 2025Article
- Near-infrared II cyanine fluorophores with large stokes shift engineered by regulating respective absorption and emission.Nature communications · 2025Article
- Emerging Image-Guided Navigation Techniques for Cardiovascular Interventions: A Scoping Review.Bioengineering (Basel, Switzerland) · 2025Review
- Advances in Organic Small Molecule-Based Fluorescent Probes for Precision Detection of Liver Diseases: A Perspective on Emerging Trends and Challenges.Journal of the American Chemical Society · 2025Review
- Activatable red/near-infrared aqueous organic phosphorescence probes for improved time-resolved bioimaging.National science review · 2025Article
- Glycyrrhizinate Monoammonium Cysteine-Loaded Lipid Nanoparticles Allow for Improved Acute Liver Injury Therapy.Pharmaceutics · 2025Article
- Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging.Nature communications · 2025Article
- The Protective Effect of Geraniol Against Hepatic Ischemia-Reperfusion Injury by Attenuating Oxidative Stress, Inflammatory Response, and Apoptosis in Rat Model.International journal of inflammation · 2025Article
- Confined semiconducting polymers with boosted NIR light-triggered HChemical science · 2024Article
- White-light activatable organic NIR-II luminescence nanomaterials for imaging-guided surgery.Nature communications · 2024Article
- Fluorescent Probes for Disease Diagnosis.Chemical reviews · 2024Review
- A novel fluorescence probe for simultaneous detection of mitochondrial viscosity in hepatic ischemia reperfusion injury models.RSC advances · 2024Article
- Electron-withdrawing inductive effects enhanced strategy for protein thiol sensing and blocking agent design.Smart molecules : open access · 2024Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatic ischemia-reperfusion injury (HIRI) is responsible for postoperative liver dysfunction and liver failure. Precise and rapid navigation of HIRI lesions is critical for early warning and timely development of pretreatment plans. Available methods for assaying liver injury fail to provide the exact location of lesions in real time intraoperatively. HIRI is intimately associated with oxidative stress which impairs lysosomal degradative function, leading to significant changes in lysosomal viscosity. Therefore, lysosomal viscosity is a potential biomarker for the precise targeting of HIRI. Hence, we developed a viscosity-activatable second near-infrared window fluorescent probe (NP-V) for the detection of lysosomal viscosity in hepatocytes and mice during HIRI. A reactive oxygen species-malondialdehyde-cathepsin B signaling pathway during HIRI was established. We further conducted high signal-to-background ratio NIR-II fluorescence imaging of HIRI mice. The contour and boundary of liver lesions were delineated, and as such the precise intraoperative resection of the lesion area was implemented. This research demonstrates the potential of NP-V as a dual-functional probe for the elucidation of HIRI pathogenesis and the direct navigation of HIRI lesions in clinical applications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.