Evidence map›Paper›PMID 35793421›Full record

ReviewMicrocirculation (New York, N.Y. : 1994)2022

Photoacoustic imaging for microcirculation.

Shubham Mirg, Kevin L Turner, Haoyang Chen, Patrick J Drew, Sri-Rajasekhar Kothapalli

Open access · greenAbstract readReview
In one paragraph

Review in Microcirculation (New York, N.Y. : 1994), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Shubham MirgDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0003-1811-6047
Kevin L TurnerDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
Haoyang ChenDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
Patrick J DrewDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
Sri-Rajasekhar KothapalliDepartment of Biomedical Engineering, Pennsylvania State University, University Park, Pennsylvania, USA.
Pennsylvania State University · US

Funding

Imaging neurovascular coupling and functional connectivity in the behaving mouseR01NS078168 · NINDS · PENNSYLVANIA STATE UNIVERSITY, THE · PI DREW, PATRICK JAMES · 2013 to 2023
$3.3M
NINDS NIH HHS R01 NS078168
6 · The paper itself

Abstract

Microcirculation facilitates the blood-tissue exchange of nutrients and regulates blood perfusion. It is, therefore, essential in maintaining tissue health. Aberrations in microcirculation are potentially indicative of underlying cardiovascular and metabolic pathologies. Thus, quantitative information about it is of great clinical relevance. Photoacoustic imaging (PAI) is a capable technique that relies on the generation of imaging contrast via the absorption of light and can image at micron-scale resolution. PAI is especially desirable to map microvasculature as hemoglobin strongly absorbs light and can generate a photoacoustic signal. This paper reviews the current state of the art for imaging microvascular networks using photoacoustic imaging. We further describe how quantitative information about blood dynamics such as the total hemoglobin concentration, oxygen saturation, and blood flow rate is obtained using PAI. We also discuss its importance in understanding key pathophysiological processes in neurovascular, cardiovascular, ophthalmic, and cancer research fields. We then discuss the current challenges and limitations of PAI and the approaches that can help overcome these limitations. Finally, we provide the reader with an overview of future trends in the field of PAI for imaging microcirculation.

Indexed as

Photoacoustic TechniquesDiagnostic ImagingHemoglobinsMicrocirculationMicrovesselsHemoglobinsAR-PAMmicrocirculation imagingmicrovasculatureOR-PAMphotoacoustic imaging

Identifiers

PMID35793421
PMCPMC9870710
OpenAlexW4284879468

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.